MCM3 and CDC6

Number of citations of the paper that reports this interaction (PubMedID 11046155)
464

Data Source:
BioGRID (affinity chromatography technology, biochemical, pull down)
HPRD (in vivo)

		MCM3	CDC6
Description		minichromosome maintenance complex component 3	cell division cycle 6
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Centrosome Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding Kinase Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding Mitotic DNA Replication Initiation	DNA Replication Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Signaling Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription
Drugs
Diseases
GWAS		Cryptococcosis in HIV infection ( 33269293)	Asthma ( 31619474)
Interacting Genes		37 interacting genes: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 HAUS1 KEAP1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TFAP2B TRIM28 YWHAQ	40 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CCNF CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 DSC2 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC OGT ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBE2K UBR1
Entrez ID		4172	990
HPRD ID		04072	04022
Ensembl ID		ENSG00000112118	ENSG00000094804
Uniprot IDs		A0A0S2Z4T1 A0A499FHX9 B4DUQ9 P25205	A0A024R1S2 Q99741
PDB IDs		6XTX 6XTY	2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?
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