MARK3 and SLC27A4

		MARK3	SLC27A4
Description		microtubule affinity regulating kinase 3	solute carrier family 27 member 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Dendrite Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Microvillus Membrane Integral Component Of Membrane Brush Border Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transporter Activity Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity Oleoyl-CoA Ligase Activity Oleate Transmembrane Transporter Activity
	Biological Process	Microtubule Cytoskeleton Organization Protein Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-serine Autophosphorylation	Medium-chain Fatty Acid Transport Long-chain Fatty Acid Metabolic Process Fatty Acid Metabolic Process Response To Nutrient Fatty Acid Transport Long-chain Fatty Acid Transport Very Long-chain Fatty Acid Catabolic Process Positive Regulation Of Apoptotic Process Skin Development Glucose Import In Response To Insulin Stimulus Long-chain Fatty Acid Import Into Cell Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Activation Of GTPase Activity Transport Across Blood-brain Barrier Lipid Transport Across Blood-brain Barrier
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) Transport of fatty acids
Drugs		Fostamatinib
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Cutaneous melanoma or hair colour ( 32341527) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Optic disc size ( 31809533) PR interval ( 32439900) Systolic blood pressure ( 30224653 30578418) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)	Body mass index ( 26426971)
Interacting Genes		35 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CDC42BPB CHGB CLASP1 CLASP2 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 HMOX2 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ RCOR3 RECQL SAAL1 SFN SLC27A4 TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ	4 interacting genes: EPS8 MARK3 NOTCH4 TENT5B
Entrez ID		4140	10999
HPRD ID		04058	09172
Ensembl ID		ENSG00000075413	ENSG00000167114
Uniprot IDs		A0A7I2V2E3 A0A7I2V3B9 A0A7I2V5G3 A0A7I2V639 A0A7I2YQF7 H0YNV4 P27448 Q86U11	A0A024R8D2 Q6P1M0
PDB IDs		2QNJ 3FE3
Enriched GO Terms of Interacting Partners?
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