MAP2 and TTBK1

Number of citations of the paper that reports this interaction (PubMedID 7556643)
22

Data Source:
HPRD (in vitro)

		MAP2	TTBK1
Description		microtubule associated protein 2	tau tubulin kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Microtubule Associated Complex Dendrite Dendrite Cytoplasm Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Axon Hillock Dendritic Growth Cone Main Axon Dendritic Branch Basal Dendrite Primary Dendrite Distal Dendrite Apical Distal Dendrite Dendritic Filopodium Proximal Dendrite Proximal Neuron Projection	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Dystroglycan Binding Structural Molecule Activity Protein Binding Calmodulin Binding Microtubule Binding Tau Protein Binding	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Dendrite Development Central Nervous System Neuron Development Negative Regulation Of Axon Extension Regulation Of Microtubule Polymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Dendrite Morphogenesis Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Anterograde Synaptic Vesicle Transport Regulation Of Cellular Protein Localization Negative Regulation Of Microtubule Binding	Protein Phosphorylation Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Substantia Nigra Development Negative Regulation Of Protein Binding Positive Regulation Of Protein Polymerization Positive Regulation Of Astrocyte Activation Positive Regulation Of Microglial Cell Activation Positive Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways
Drugs		Estramustine Paclitaxel Docetaxel
Diseases
GWAS		Adventurousness ( 30643258) Bipolar disorder ( 31043756) Body mass index ( 28552196) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Handedness (Left-handed vs. non-left-handed) ( 31504236 30980028) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 28552196) LDL cholesterol levels in HIV infection ( 33109212) Left-handedness ( 32989287) Leftâ€“right brain asymmetry ( 33723403) Skin and soft tissue infections ( 33662382) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adult hearing difficulty ( 31564434) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Body size at age 10 ( 32376654) Diastolic blood pressure ( 29403010) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mean arterial pressure ( 29403010) Pulse pressure ( 28739976) Red blood cell count ( 32888494) Systolic blood pressure ( 26390057 29403010 28739976)
Interacting Genes		26 interacting genes: ACSL3 ACTB ACTN1 APOE APP CPEB1 DAG1 FYN GRB2 GRIN1 GRIN2D JUNB MARK1 MARK3 MARK4 MDM2 MYO7A NEDD4L NEFL PAFAH1B1 PLEC PRKACA PRKAR2A SRC TTBK1 TUBA1A	5 interacting genes: CDK5R1 CSN1S1 MAP2 MAPT TUBB
Entrez ID		4133	84630
HPRD ID		01140	11653
Ensembl ID		ENSG00000078018	ENSG00000146216
Uniprot IDs		A0A024R3Y8 A0A024R3Z1 A0A024R409 P11137 Q6NYC5	Q5TCY1
PDB IDs			4BTJ 4BTK 4BTM 4NFM 4NFN
Enriched GO Terms of Interacting Partners?
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