MIR140 and C1QBP

Number of citations of the paper that reports this interaction (PubMedID 28431233)
92

Data Source:
BioGRID (unspecified method)

		MIR140	C1QBP
Description		microRNA 140	complement C1q binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Cell Surface Membrane Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	RNA Polymerase II Complex Binding MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing	Complement Component C1q Complex Binding Transcription Corepressor Activity MRNA Binding Protein Kinase C Binding Protein Binding Hyaluronic Acid Binding Transcription Factor Binding Kininogen Binding Adrenergic Receptor Binding Mitochondrial Ribosome Binding
	Biological Process	Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of BMP Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Gene Silencing By MiRNA Defense Response To Bacterium Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Vascular Endothelial Growth Factor Production Cellular Response To Amyloid-beta Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	Negative Regulation Of Transcription By RNA Polymerase II MRNA Processing Apoptotic Process Immune Response Complement Activation, Classical Pathway RNA Splicing Phosphatidylinositol 3-kinase Signaling Regulation Of Complement Activation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Defense Response To Virus Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Translation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis
Pathways			Apoptotic factor-mediated response Intrinsic Pathway of Fibrin Clot Formation RHOA GTPase cycle RHOC GTPase cycle Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Drugs			Hyaluronic acid Copper
Diseases
GWAS		Body mass index ( 26426971)	Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		68 interacting genes: ADARB1 AIMP1 APOBEC3B C1QBP CELF1 CELF2 CRTAP CSTF1 DARS1 DDX1 DDX21 DDX3X DDX49 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 NOL6 NONO NUDT21 PDCD11 PIKFYVE PIP5K1A PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RTCB SF3B1 SF3B3 SFPQ SYNCRIP TAF15 TRA2A TRA2B UPF1 UTP20 YBX1 YBX3	109 interacting genes: ABR C1QA CEBPA COIL CRK DIO3 DUX4 EMP1 EXOSC6 FXR1 GAB1 GABRB1 HABP4 HMGB1 HMGB2 HNRNPD HRK KLF1 MAPK1 MAPK3 MBD1 MBD2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MMP14 MRPL11 NFKBIE NFYB PRKCA PRKCD PRKCZ PRKD1 PRRC2A SHANK3 SRSF1 SRSF9 TOP3B YBX1 YWHAB YWHAG
Entrez ID		406932	708
HPRD ID			03168
Ensembl ID		ENSG00000208017	ENSG00000108561
Uniprot IDs			Q07021
PDB IDs			1P32 3RPX 6SZW
Enriched GO Terms of Interacting Partners?
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