LTC4S and MGST1

Number of citations of the paper that reports this interaction (PubMedID 11034337)
3

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, in vitro)

		LTC4S	MGST1
Description		leukotriene C4 synthase	microsomal glutathione S-transferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle	Nucleus Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Azurophil Granule Membrane Apical Part Of Cell
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding Identical Protein Binding	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Identical Protein Binding Glutathione Binding
	Biological Process	Leukotriene Metabolic Process Leukotriene Biosynthetic Process Long-chain Fatty Acid Biosynthetic Process Regulation Of Catalytic Activity Cellular Oxidant Detoxification	Response To Xenobiotic Stimulus Response To Organonitrogen Compound Response To Lipopolysaccharide Leydig Cell Differentiation Glutathione Transport Cellular Response To Lipid Hydroperoxide Cellular Oxidant Detoxification
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)	Glutathione conjugation Aflatoxin activation and detoxification Neutrophil degranulation
Drugs		Glutathione Azelastine	Glutathione Glutathione disulfide
Diseases
GWAS			Barrett's esophagus or Esophageal adenocarcinoma ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Bell's palsy ( 33602968) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Household income (MTAG) ( 31844048) Metabolite levels ( 23823483) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Visceral fat ( 22589738)
Interacting Genes		13 interacting genes: ALOX5 ALOX5AP BACE2 CD79A CREB3L1 EBP FFAR3 FXYD3 GPR152 GPR42 MGST1 SLC7A14 TMEM52B	8 interacting genes: EGF FXYD3 FZD7 LTC4S NELFB SIGLEC12 TNFRSF10C VIP
Entrez ID		4056	4257
HPRD ID		02004	00705
Ensembl ID		ENSG00000213316	ENSG00000008394
Uniprot IDs		Q16873	A0A024RAX2 P10620
PDB IDs		2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4BPM 4J7T 4J7Y 4JC7 4JCZ 4JRZ 4WAB 5HV9 6R7D
Enriched GO Terms of Interacting Partners?
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