LRP6 and ANTXR2

Number of citations of the paper that reports this interaction (PubMedID 16564009)
54

Data Source:
HPRD (in vivo, in vitro)

		LRP6	ANTXR2
Description		LDL receptor related protein 6	ANTXR cell adhesion molecule 2
Image
GO Annotations	Cellular Component	Extracellular Region Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Cell Surface Integral Component Of Membrane Cytoplasmic Vesicle Early Endosome Membrane Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome	Extracellular Region Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Endosome Membrane Integral Component Of Membrane
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding Kinase Inhibitor Activity Toxin Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway Coreceptor Activity Involved In Canonical Wnt Signaling Pathway	Transmembrane Signaling Receptor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Neural Crest Formation Neural Crest Cell Differentiation Wnt Signaling Pathway Negative Regulation Of Smooth Muscle Cell Apoptotic Process Response To Peptide Hormone Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Protein Localization To Plasma Membrane Receptor-mediated Endocytosis Involved In Cholesterol Transport Wnt Signaling Pathway Involved In Somitogenesis Cell-cell Adhesion Toxin Transport Midbrain Dopaminergic Neuron Differentiation Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation	Toxin Transport
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs			MDX-1303
Diseases
GWAS		Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Coronary artery calcification ( 23870195) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tandem gait ( 26219847)	Adult body size ( 32376654) Ankylosing spondylitis ( 21743469 20062062) Bipolar disorder (inflammation and infection response interaction) ( 25781172) Carotid plaque burden ( 28282560) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Essential hypertension (time to event) ( 32589924) Hand grip strength ( 29691431) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Myopia ( 27182965) Neutrophil percentage of white cells ( 32888494 27863252) Refractive error ( 32231278) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Spherical equivalent or myopia (age of diagnosis) ( 29808027) White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 CKLF DKK1 DKK2 FZD5 FZD8 GSK3A GSK3B LRRK2 MDK SERPINF1 TLNRD1 WNT1 WNT3A	11 interacting genes: COL4A2 COL4A3 COL4A4 COL4A5 DDX10 FRAS1 LAMB1 LAMC1 LRP6 RAP1GDS1 SMAD2
Entrez ID		4040	118429
HPRD ID		04617	07452
Ensembl ID		ENSG00000070018	ENSG00000163297
Uniprot IDs		O75581	A4FUA5 J3KPY9 P58335 Q32Q26
PDB IDs		3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6 4NM5 4NM7 5AIR 5FWW 5GJE 6H15 6H16 6L6R	1SHT 1SHU 1T6B 1TZN
Enriched GO Terms of Interacting Partners?
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