HiPPIP

LRP2 and LPA

  • Number of citations of the paper that reports this interaction (PubMedID 10073957)
  • 11
  • Data Source:
  • HPRD (in vitro)

LRP2

LPA
Description LDL receptor related protein 2 lipoprotein(a)
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Abdominal aortic aneurysm ( 32981348)
  • Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081)
  • Aortic valve stenosis ( 29511194)
  • Aortic-valve calcification ( 23388002)
  • Apolipoprotein A1 levels ( 32203549 33730874)
  • Apolipoprotein B levels ( 32203549)
  • Blood protein levels ( 28240269)
  • Body mass index ( 26426971)
  • Body mass index (age>50) ( 26426971)
  • Body mass index x sex x age interaction (4df test) ( 26426971)
  • Body shape index ( 34021172)
  • C-reactive protein levels ( 33339817)
  • Calcific aortic valve stenosis ( 32141789)
  • Cholesterol, total ( 24097068 28270201 25961943 20686565)
  • Coronary artery disease ( 32469254 29212778 24262325 30104761 26343387 28714974 33020668)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Coronary artery disease in diabetes ( 30003307)
  • Coronary artery disease or ischemic stroke ( 24262325)
  • Coronary artery disease or large artery stroke ( 24262325)
  • Coronary heart disease ( 19198611 21378990)
  • End stage renal disease x APOL1 genotype interaction ( 29885931)
  • HDL cholesterol ( 25961943 20686565)
  • HDL cholesterol levels ( 32203549)
  • HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Heart failure ( 31919418)
  • High density lipoprotein cholesterol levels ( 33339817)
  • Hip circumference adjusted for BMI ( 34021172)
  • Ischemic stroke (large artery atherosclerosis) ( 29531354)
  • LDL cholesterol ( 24097068 30275531 25961943 20686565)
  • LDL cholesterol levels ( 32203549)
  • LDL cholesterol levels in current drinkers ( 30698716)
  • LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Lipid or lipoprotein levels ( 23696881)
  • Lipoprotein (a) levels ( 26377243 30108283 33115273 28512139)
  • Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284)
  • Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334)
  • Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643)
  • Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms ( 28512139)
  • Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302)
  • Low density lipoprotein cholesterol levels ( 32154731 33339817)
  • Low density lipoprotein cholesterol levels (on statin treatment) ( 31969989)
  • Lp (a) levels ( 21900290 19124843)
  • Medication use (agents acting on the renin-angiotensin system) ( 31015401)
  • Medication use (antithrombotic agents) ( 31015401)
  • Medication use (beta blocking agents) ( 31015401)
  • Medication use (HMG CoA reductase inhibitors) ( 31015401)
  • Medication use (salicylic acid and derivatives) ( 31015401)
  • Medication use (vasodilators used in cardiac diseases) ( 31015401)
  • Metabolic syndrome ( 31589552)
  • Metabolite levels (lipoprotein measures) ( 27005778)
  • Minimum ankle–brachial index ( 31285632)
  • Monocyte early outgrowth colony forming units ( 21493818)
  • Myocardial infarction ( 33532862 26343387)
  • Parental lifespan ( 30642433 29030599)
  • Parental longevity (both parents in top 10%) ( 29227965)
  • Parental longevity (combined parental age at death) ( 29227965)
  • Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
  • Parental longevity (father's age at death) ( 31484785 29227965)
  • Parental longevity (father's attained age) ( 29227965)
  • Parental longevity (mother's age at death or mother's attained age) ( 31484785)
  • Parental longevity (mother's age at death) ( 29227965)
  • Parental longevity (mother's attained age) ( 29227965)
  • Peripheral artery disease ( 31285632)
  • Plasma plasminogen levels ( 25208887)
  • Plateletcrit ( 32888494)
  • Protein quantitative trait loci ( 18464913)
  • Response to statin therapy ( 22368281)
  • Response to statins (LDL cholesterol change) ( 25350695 22331829 31969989)
  • Response to statins (LDL cholesterol percent change) ( 31969989)
  • Total cholesterol levels ( 28334899 33339817 30275531)
  • Triglyceride levels ( 32203549 32154731)
  • Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Triglycerides ( 30275531 25961943)
  • Urinary albumin excretion ( 32277301)
  • Waist-hip index ( 34021172)
  • Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes 57 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU COL3A1 CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 EIPR1 GALNT3 GC GIPC1 GPRASP1 HK3 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TANK TBR1 TG THBS1 TLN1 TTR 9 interacting genes: APOH CANX CELA1 ELANE FBLN5 FGB FN1 LRP2 MMP12
Entrez ID 4036 4018
HPRD ID 02509 01063
Ensembl ID ENSG00000081479 ENSG00000198670
Uniprot IDs P98164 Q7Z5C0 Q7Z5C1
PDB IDs 2M0P
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?