FADS3 and DHRSX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FADS3	DHRSX
Description		fatty acid desaturase 3	dehydrogenase/reductase X-linked
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Extracellular Region
	Molecular Function	Molecular_function Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water	Protein Binding Oxidoreductase Activity
	Biological Process	Lipid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process	Positive Regulation Of Autophagy
Pathways
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma (adult onset) ( 31036433) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Cholesterol, total ( 24097068 19060911 25961943 20686565) Fatty acid desaturase activity (serum) ( 30453627) Glycated hemoglobin levels ( 34059833) Glycerophospholipid levels ( 26068415) HDL cholesterol ( 24097068 19060906 19060911 25961943 20686565) HDL cholesterol levels ( 28334899) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 24097068 19060911 25961943 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 23823483 23378610 22916037) Oleic acid (18:1n-9) levels ( 23362303) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30423114 24390342) Serum metabolite levels (CMS) ( 31636271) Sphingolipid d18:1/d18:2 ratio ( 31862735) Sphingolipid levels ( 19798445 26068415 22359512) Stearic acid (18:0) levels ( 23362303) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 24097068 19060906 25961943 20686565) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: DHRSX MDN1	20 interacting genes: APOC1 APP AQP6 ASPH ATXN1 CIDEB CMTM5 FADS3 GCNT3 HSD17B11 PGRMC2 PIGP RETREG3 RUSF1 TLCD4 TMEM143 TMEM14B TMEM31 TMEM86B ZDHHC15
Entrez ID		3995	207063
HPRD ID		07547	16803
Ensembl ID		ENSG00000221968	ENSG00000169084
Uniprot IDs		A0A024R564 Q9Y5Q0	Q8N5I4
PDB IDs
Enriched GO Terms of Interacting Partners?
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