LIFR and LIF

Number of citations of the paper that reports this interaction (PubMedID 12601009)
3

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		LIFR	LIF
Description		LIF receptor subunit alpha	LIF interleukin 6 family cytokine
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex Extracellular Exosome	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding	Signaling Receptor Binding Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway	Blood Vessel Remodeling Immune Response Tyrosine Phosphorylation Of STAT Protein Multicellular Organism Development Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Stem Cell Population Maintenance Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Regulation Of Cell Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Decidualization Negative Regulation Of Hormone Secretion Lung Alveolus Development Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Lung Vasculature Development Lung Lobe Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Histone H3-K27 Acetylation Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways		IL-6-type cytokine receptor ligand interactions RUNX1 regulates transcription of genes involved in interleukin signaling	Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Pursuit maintenance gain ( 29064472) Ulcerative colitis ( 26192919)	Delirium ( 29631748) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574) Nephropathy ( 21399633) Tonsillectomy ( 27941131)
Interacting Genes		12 interacting genes: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6	7 interacting genes: HPGDS IL6ST KRT31 KRTAP12-3 LIFR NCALD NF2
Entrez ID		3977	3976
HPRD ID		01048	08869
Ensembl ID		ENSG00000113594	ENSG00000128342
Uniprot IDs		A8K1Z4 P42702	P15018
PDB IDs		3E0G	1EMR 1PVH 2Q7N
Enriched GO Terms of Interacting Partners?
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