ARHGDIA and ACTL6A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARHGDIA	ACTL6A
Description		Rho GDP dissociation inhibitor alpha	actin like 6A
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GO Annotations	Cellular Component	Immunological Synapse Nucleus Cytosol Cytoskeleton Membrane Synapse Extracellular Exosome	Chromatin Nucleus Nucleoplasm Plasma Membrane SWI/SNF Complex Ino80 Complex Protein-containing Complex NuA4 Histone Acetyltransferase Complex NpBAF Complex
	Molecular Function	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Fatty Acid Binding Protein Binding Protein Kinase Binding Small GTPase Binding Hsp90 Protein Binding	Chromatin Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Regulation Of Cell Shape Negative Regulation Of Cell Migration Regulation Of Protein Localization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Redox State Semaphorin-plexin Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization	Blastocyst Formation Neural Retina Development DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Signal Transduction Nervous System Development Spinal Cord Development Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated
Pathways		Axonal growth inhibition (RHOA activation) Axonal growth stimulation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle	HATs acetylate histones RMTs methylate histone arginines UCH proteinases DNA Damage Recognition in GG-NER RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS			Pars opercularis volume ( 31530798)
Interacting Genes		41 interacting genes: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B EP300 FEN1 HAAO HDAC6 HERPUD1 IKBKG JUP KAT2B MAPK6 NEDD4L POT1 RAC1 RAC2 RAC3 RDX RHOA RHOG RHOH SDHC SH3GL3 SIRT2 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2I UBE2L6 UBE2R2 UFM1 VAV1	16 interacting genes: ARHGDIA CDK2 CDK9 ERO1B EWSR1 FLII MRGBP MYC OGT POLR2A PTEN RELA RUVBL1 SMARCA2 SMARCA4 TRRAP
Entrez ID		396	86
HPRD ID		03565	05389
Ensembl ID		ENSG00000141522	ENSG00000136518
Uniprot IDs		J3QQX2 P52565 V9HWE8	O96019
PDB IDs		1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0 2N80	6LTJ
Enriched GO Terms of Interacting Partners?
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