LCN2 and UBE3A

Number of citations of the paper that reports this interaction (PubMedID 31329371)
1

Data Source:
BioGRID (pull down)

		LCN2	UBE3A
Description		lipocalin 2	ubiquitin protein ligase E3A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Specific Granule Lumen Extracellular Exosome	Proteasome Complex Nucleus Cytosol
	Molecular Function	Protease Binding Iron Ion Binding Protein Binding Small Molecule Binding Identical Protein Binding Enterobactin Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Apoptotic Process Acute-phase Response Response To Xenobiotic Stimulus Response To Herbicide Response To Blue Light Response To Iron(II) Ion Response To Mycotoxin Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Siderophore Transport Positive Regulation Of Cell Projection Organization Cellular Response To Increased Oxygen Levels Defense Response To Bacterium Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Oxygen-glucose Deprivation Sequestering Of Iron Ion Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Iron Ion Import Across Plasma Membrane Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Tube Morphogenesis Cellular Response To Nerve Growth Factor Stimulus	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Progesterone Sperm Entry Locomotory Exploration Behavior Response To Cocaine Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Progesterone Receptor Signaling Pathway Protein Autoubiquitination Prostate Gland Growth Negative Regulation Of Dendritic Spine Morphogenesis Motor Learning Protein K48-linked Ubiquitination Positive Regulation Of Golgi Lumen Acidification Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Methyl nonanoate 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)
Interacting Genes		62 interacting genes: ALDH7A1 ALKBH4 ASB10 ASPH BEX2 BMF C20orf85 CAMLG CCNC CDSN CHIC2 CLMP CTDSP2 EHHADH FAAP20 FAM25A FAM25C FAM25G HDDC2 HGF LAIR2 LNPEP LRP2 LY96 MAGED4B MMP2 MMP9 MSRB3 MYDGF NDUFB2 NEIL2 ODAPH P4HB PDIA4 PELI1 PICK1 PIN1 POLL POU4F2 PRKAA2 PTRH1 RAMP2 SCNM1 SEC61G SGTA SGTB TBC1D21 TRAPPC2L TRH TRIAP1 TRIM32 TSG101 TTC23 TXN2 UBASH3A UBE2F UBE3A UBQLN1 UBQLN2 VEZF1 XRN2 ZBED1	150 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ALDH1A2 ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CALR CAPN3 CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CKB CRP CTNNB1 DAZAP2 DLG1 E2F1 EAPP EEF1A2 EID1 EIF4G1 EML1 ENO1 ENO2 ESR1 FAF2 GFAP GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA2 HSPA4 HSPA5 IL24 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK LCN2 MAGEA12 MAGEA8 MAPK1 MAPK10 MARF1 MCM7 MDM1 MDM2 MEOX2 MSTO1 MYCBP NBPF14 NDUFA13 NELFCD NOMO2 NR4A3 NUMBL PAICS PARVA PAX5 PAX6 PDE1B PDIA3 PDIA6 PGK1 PGR PKM PML POLE4 PPIA PPP1R3F PRAG1 PRDX1 PRKACA PRMT5 PRSS1 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RNF152 RPS15A RYBP SACS SCAMP1 SCRIB SERPINB2 SET SHBG SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 TUBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN1 UBQLN2 WBP2 YOD1 YWHAE YWHAG YWHAZ ZNF250 ZNF446
Entrez ID		3934	7337
HPRD ID		02551	03375
Ensembl ID		ENSG00000148346	ENSG00000114062
Uniprot IDs		P80188	Q05086 Q9H2G0
PDB IDs		1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U0D 4GH7 4IAW 4IAX 4K19 4MVI 4MVK 4MVL 4QAE 4ZFX 4ZHC 4ZHD 4ZHF 4ZHG 4ZHH 5JR8 5KHP 5KIC 5KID 5MHH 5N47 5N48 5NKN 6GQZ 6GR0 6O5D 6QMU 6S8V 6SUA	1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19
Enriched GO Terms of Interacting Partners?
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