LAMB1 and ANTXR2

Number of citations of the paper that reports this interaction (PubMedID 11683410)
133

Data Source:
BioGRID (pull down)

		LAMB1	ANTXR2
Description		laminin subunit beta 1	ANTXR cell adhesion molecule 2
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-2 Complex Extracellular Space Endoplasmic Reticulum Lumen Laminin Complex Laminin-8 Complex Laminin-10 Complex Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Endosome Membrane Integral Component Of Membrane
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Metal Ion Binding
	Biological Process	Cell Adhesion Animal Organ Morphogenesis Tissue Development Cell Migration Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Neuron Projection Development Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Odontogenesis Positive Regulation Of Epithelial Cell Proliferation Basement Membrane Assembly	Toxin Transport
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Lanoteplase	MDX-1303
Diseases
GWAS		Body shape index ( 34021172) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Latent naming speed ( 30995994) Pneumoconiosis in silica exposure ( 24986923) Rapid alternating stimulus test for letters/numbers ( 30995994) Rapid automised naming and rapid alternating stimulus test performance ( 30995994) Rapid automised naming of letters ( 30995994) Ulcerative colitis ( 19915572 28067908 20228799 19122664) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adult body size ( 32376654) Ankylosing spondylitis ( 21743469 20062062) Bipolar disorder (inflammation and infection response interaction) ( 25781172) Carotid plaque burden ( 28282560) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Essential hypertension (time to event) ( 32589924) Hand grip strength ( 29691431) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Myopia ( 27182965) Neutrophil percentage of white cells ( 32888494 27863252) Refractive error ( 32231278) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Spherical equivalent or myopia (age of diagnosis) ( 29808027) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: ACHE ANTXR2 ATXN7 ATXN7L2 CACNA1A CD79A COL6A1 ERBIN GFI1B GPR152 LMNA PRKAR2B PSMC5 UBC UBQLN1	11 interacting genes: COL4A2 COL4A3 COL4A4 COL4A5 DDX10 FRAS1 LAMB1 LAMC1 LRP6 RAP1GDS1 SMAD2
Entrez ID		3912	118429
HPRD ID		01029	07452
Ensembl ID		ENSG00000091136	ENSG00000163297
Uniprot IDs		G3XAI2 P07942 Q8TAS6	A4FUA5 J3KPY9 P58335 Q32Q26
PDB IDs		5XAU	1SHT 1SHU 1T6B 1TZN
Enriched GO Terms of Interacting Partners?
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