LAG3 and KCNA1

		LAG3	KCNA1
Description		lymphocyte activating 3	potassium voltage-gated channel subfamily A member 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Integral Component Of Membrane Apical Plasma Membrane Cell Junction Dendrite Cytoplasmic Vesicle Paranode Region Of Axon Presynaptic Membrane Neuronal Cell Body Perikaryon Axon Terminus Juxtaparanode Region Of Axon Calyx Of Held Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding MHC Class II Protein Binding	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Transmembrane Transporter Activity Disordered Domain Specific Binding Voltage-gated Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response	Startle Response Potassium Ion Transport Regulation Of Muscle Contraction Chemical Synaptic Transmission Neuroblast Proliferation Cell Communication By Electrical Coupling Magnesium Ion Homeostasis Neuronal Action Potential Hippocampus Development Neuronal Signal Transduction Cellular Protein Localization Regulation Of Membrane Potential Neuromuscular Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Homooligomerization Regulation Of Postsynaptic Membrane Potential Cellular Response To Magnesium Ion Potassium Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential Positive Regulation Of Voltage-gated Potassium Channel Activity
Pathways		MHC class II antigen presentation	Voltage gated Potassium channels
Drugs			Enflurane Amitriptyline Isoflurane Methoxyflurane Promethazine Miconazole Desflurane Dalfampridine Tetraethylammonium Amifampridine
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		7 interacting genes: ALCAM CEBPZ CENPJ CLEC4D GNAI2 KCNA1 UBE2E3	18 interacting genes: APOL2 DLG1 DLG4 DOLK FCER1G GPR152 GPR42 IER3IP1 JAGN1 KCNA10 KCNA3 KCNE4 LAG3 MAL NOMO1 SGTA TMEM14B TMEM86A
Entrez ID		3902	3736
HPRD ID		01077	08885
Ensembl ID		ENSG00000089692	ENSG00000111262
Uniprot IDs		P18627	Q09470
PDB IDs			2AFL
Enriched GO Terms of Interacting Partners?
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