AFF3 and IL18R1

		AFF3	IL18R1
Description		AF4/FMR2 family member 3	interleukin 18 receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Super Elongation Complex	Plasma Membrane Interleukin-18 Receptor Complex
	Molecular Function	Double-stranded DNA Binding DNA-binding Transcription Factor Activity	Interleukin-1 Receptor Activity Protein Binding Signaling Receptor Activity Interleukin-18 Binding Interleukin-18 Receptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Response To Tumor Necrosis Factor Embryonic Hindlimb Morphogenesis	Inflammatory Response Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Interferon-gamma Production Interleukin-18-mediated Signaling Pathway T-helper 1 Cell Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways			Interleukin-37 signaling Interleukin-18 signaling
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 27798627) Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 34103634) Autoimmune traits (pleiotropy) ( 30572963) Body shape index ( 34021172) Cannabis dependence symptom count ( 27028160) Celiac disease ( 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Extremely high intelligence ( 29520040) Gastroesophageal reflux disease ( 34187846 31527586) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Height ( 31217584) Hip circumference adjusted for BMI ( 34021172) Household income ( 27818178) Household income (MTAG) ( 31844048) IgG levels ( 28628107) Immature fraction of reticulocytes ( 32888494) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29617998) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Multisite chronic pain ( 33830993) Non-albumin protein levels ( 29403010) Number of children ever born ( 27798627) Plateletcrit ( 32888494 27863252) Red blood cell count ( 27863252) Refractive astigmatism ( 30306274) Regular attendance at a religious group ( 29970889) Rheumatoid arthritis ( 30423114 24782177 30572963 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum total protein level ( 29403010) Triglyceride levels ( 34074324) Type 1 diabetes ( 25751624 17554260 34127860) Type 1 diabetes nephropathy ( 23028342) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) Asthma ( 23028483 31361310 31959851 30929738 20860503 31619474 26620591 29273806 22561531) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738 29273806) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Atypical femoral fracture in phosphonate treatment ( 31006051) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488 28240269) Celiac disease ( 20190752 18311140) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Eczema ( 31361310) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Pediatric autoimmune diseases ( 26301688) Polymyositis ( 26362759) Primary biliary cholangitis ( 26394269) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		5 interacting genes: DPP8 GPR137B IL18R1 IL18RAP ST6GAL2	6 interacting genes: AFF3 AKAP8L CD48 IL18 IL1RAP IL37
Entrez ID		3899	8809
HPRD ID		03272	05138
Ensembl ID		ENSG00000144218	ENSG00000115604
Uniprot IDs		P51826 Q8NAP7	Q13478
PDB IDs			3WO3 3WO4 4R6U
Enriched GO Terms of Interacting Partners?
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