VGLL3 and PLA2G10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		VGLL3	PLA2G10
Description		vestigial like family member 3	phospholipase A2 group X
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome
	Molecular Function		1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Phospholipid Metabolic Process Phosphatidylserine Metabolic Process Axon Guidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Arachidonic Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Cholesterol Homeostasis Regulation Of Macrophage Activation Negative Regulation Of DNA-binding Transcription Factor Activity Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonic Acid Secretion Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cholesterol Efflux Positive Regulation Of Acrosome Reaction
Pathways			Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs			Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
Diseases
GWAS		Adventurousness ( 30643258) Breast cancer ( 29059683) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) Hip index ( 34021172) Menarche (age at onset) ( 27182965 21102462) Metabolite levels ( 23823483) Molybdenum levels ( 26025379) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Prostate cancer ( 31562322 26443449) Pubertal anthropometrics ( 23449627) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)	Cholesteryl ester levels ( 31551469) Glycerophospholipid levels ( 26068415)
Interacting Genes		65 interacting genes: CDPF1 CERCAM CNFN CTRC CYSRT1 DTX2 ESM1 FAM168B FRS3 HGS INCA1 KPRP KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP4-11 KRTAP4-2 KRTAP5-11 KRTAP5-6 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-8 LASP1 LENG8 MDFI MYO15B OXER1 PCSK5 PITX1 PITX2 PLA2G10 POGZ POU2AF1 PRR22 RBPMS RUSC1 SMARCC1 SMOC1 TBX15 TEAD1 TEAD2 TEAD3 TEAD4 TEX37 TRIM42 TSC1 TSPAN4 UFSP1 YPEL3 ZNF34	50 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE GRIN2A HGS HOXC8 HR HSF4 INCA1 KPRP KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE2A LCE2B LCE2D MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 POU4F3 PPP1R32 ROR2 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10
Entrez ID		389136	8399
HPRD ID		13431	04674
Ensembl ID		ENSG00000206538	ENSG00000069764
Uniprot IDs		A8MV65	O15496
PDB IDs			1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J
Enriched GO Terms of Interacting Partners?
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