NOTCH2NLA and INPP5D

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		NOTCH2NLA	INPP5D
Description		notch 2 N-terminal like A	inositol polyphosphate-5-phosphatase D
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm	Cytosol Cytoskeleton Plasma Membrane Membrane Raft
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Notch Signaling Pathway Cerebral Cortex Development Cell Differentiation Positive Regulation Of Notch Signaling Pathway	Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Determination Of Adult Lifespan Negative Regulation Of Signal Transduction Immunoglobulin Mediated Immune Response Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Phosphatidylinositol Dephosphorylation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways			Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PECAM1 interactions Interleukin receptor SHC signaling
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Contrast sensitivity ( 24152035) Crohn's disease ( 22412388 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum alkaline phosphatase levels ( 33547301) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		359 interacting genes: ACY3 ADAM12 ADAMTSL3 ADAMTSL4 ADAMTSL5 ADCK5 AGXT ALDH16A1 ALDH3B1 ALPI ALPP ANKS1A AQP1 AQP5 ARID3A ASPSCR1 ATG9A ATP5F1D BCAM BCL6B BLCAP BMP7 BRME1 C11orf87 C5orf60 CA6 CARHSP1 CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CELF5 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A CNNM3 COL8A1 CRACR2A CRCT1 CREB5 CRH CRY2 CSF1 CST2 CST9L CTNNBIP1 CTSG CTSZ CXCL16 CXCL5 CYHR1 CYP21A2 CYSRT1 DAGLB DALRD3 DBH DGCR6 DGKQ DHRS1 DMRT3 DNAL4 DOCK2 DRD5 EFNA3 EIF4E2 ELANE EMC7 EPHB6 ESR2 F10 FAAH FADS2 FAM124B FAM221A FAM71C FAM71E2 FAM74A4 FAM90A1 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 FTHL17 FZD10 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 H2AC15 HAPLN2 HBA1 HBA2 HBZ HCK HHEX HOXA1 HOXB9 HOXC8 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL10 IL2RG INO80B INPP5D INS ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KIF1A KLHL38 KLK8 KPRP KRT20 KRT83 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LIMS2 LIN7A LINC00526 LINC00656 LMNTD2 LMO2 LNX1 LONRF3 LRCH4 LRFN4 LYVE1 MACO1 MAPKBP1 MARK4 MATN3 MELTF MFSD13A MOS MRGBP MRPL40 MTA1 MVP MXD3 MXI1 MYO15B MYPOP NAB2 NAXD NECTIN2 NECTIN3 NEDD9 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NTM NTN4 NUBP2 NUFIP2 OLFM2 OTX1 P2RX4 P2RX7 P2RY6 PCED1A PCED1B PCSK5 PDE9A PGAP6 PGLS PHLDA1 PID1 PIGS PLEKHN1 PLPP2 PLSCR4 POLR2G POM121L8P POMGNT2 PRF1 PRKAA2 PRPF31 PRPS2 PRR35 PSMA1 PSMG2 PTGER3 PTK7 PTPMT1 PTPN23 PVR QPRT R3HDM2 RAB3IL1 RAMP3 RASD1 RCHY1 RECK RET RGL2 RNF111 RPS19BP1 RPS28 RTN4RL1 SCNM1 SDCBP SELENOM SEMA3B SEMA4C SHANK3 SHFL SLC22A23 SLC22A5 SLC23A1 SLC25A10 SLC25A6 SLC43A2 SLC5A5 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA24 SPATA8 SPG7 SPINK2 SPPL2C SPRY1 STAC STK16 TAPBPL TBC1D10C TBC1D16 TCAF1 TEDC2 THAP7 THEMIS2 TINAGL1 TLE5 TMEFF2 TMEM150A TMEM231 TMEM41A TMIE TNIP3 TNK2 TNP2 TNS2 TRAPPC14 TRIM27 TRIM42 TROAP TRPV6 TSPAN4 TTPA TXNDC5 UBQLN4 UTP23 UXT VASN WDR25 WT1-AS XCL2 YIPF3 ZDHHC1 ZFYVE21 ZNF124 ZNF319 ZNF32 ZNF330 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF446 ZNF497 ZNF580 ZNF581 ZNF587 ZNF648 ZNF672 ZNF688 ZNF786 ZNF837	46 interacting genes: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R CYSRT1 DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR1B FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP6-3 LILRB4 LYN MET NOTCH2NLA PAX6 PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 SLAMF1 XIAP ZDHHC17
Entrez ID		388677	3635
HPRD ID		14833	09033
Ensembl ID		ENSG00000264343	ENSG00000168918
Uniprot IDs		P0DPK4 Q7Z3S9	Q92835
PDB IDs			2YSX 5RW2 5RW3 5RW4 5RW5 5RW6 5RW7 5RW8 5RW9 5RWA 5RWB 5RWC 5RWD 5RWE 5RWF 5RWG 5RWH 5RWI 5RWJ 5RWK 5RWL 5RWM 5RWN 5RWO 5RWP 5RWQ 5RWR 5RWS 5RWT 5RWU 5RWV 5RWW 5RWX 5RWY 5RWZ 5RX0 5RX1 5RX2 5RX3 5RX4 5RX5 5RX6 5RX7 5RX8 5RX9 5RXA 5RXB 5RXC 5RXD 5RXE 5RXF 5RXG 5RXH 5RXI 5RXJ 5RXK 5RXL 5RXM 5RXO 5RXP 5RXQ 5RXR 5RXS 5RXT 5RXU 5RXV 5RXW 5RXX 5RXY 5RXZ 5RY0 5RY1 5RY2 5RY3 5RY4 5RY5 5RY6 5RY7 5RY8 5RY9 5RYA 5RYB 5RYC 5RYD 5RYE 5RYF 5RYG 5RYH 5RYI 5RYJ 5RYK 5RYL 6IBD 6XY7
Enriched GO Terms of Interacting Partners?
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