KIF5A and TP53BP2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KIF5A	TP53BP2
Description		kinesin family member 5A	tumor protein p53 binding protein 2
Image
GO Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Dendrite Cytoplasm Ciliary Rootlet Perikaryon Synapse Perinuclear Region Of Cytoplasm Axon Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Kinesin Binding	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Microtubule-based Movement Chemical Synaptic Transmission Axon Guidance Vesicle-mediated Transport Cytoskeleton-dependent Intracellular Transport Synaptic Vesicle Transport Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Retrograde Neuronal Dense Core Vesicle Transport	Cell Cycle Signal Transduction Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Neuron Death
Pathways		MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 29566793) Rheumatoid arthritis ( 24449572 18794853) Smoking initiation (ever regular vs never regular) ( 30679032)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Triptolide cytotoxicity ( 26121980)
Interacting Genes		21 interacting genes: CREBBP DTNB ITSN1 KCNE3 KIF5B KIF5C KLC3 MAP4K4 MAPK10 NCOA2 NDEL1 PIN1 RAPGEF2 SMN1 TK1 TP53BP2 TRIM55 TRIM63 TSC1 TSG101 YAP1	124 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC85A CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 DISC1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP HYOU1 INSYN2A IQUB KDM1A KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RASSF8 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG YWHAQ ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575
Entrez ID		3798	7159
HPRD ID		09108	11803
Ensembl ID		ENSG00000155980	ENSG00000143514
Uniprot IDs		Q12840	Q13625
PDB IDs		4UXT 4UXY 4UY0	1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?
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