KCNJ4 and GNGT2

Number of citations of the paper that reports this interaction (PubMedID 8943291)
11

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		KCNJ4	GNGT2
Description		potassium inwardly rectifying channel subfamily J member 4	G protein subunit gamma transducin 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane Postsynaptic Membrane	Heterotrimeric G-protein Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding PDZ Domain Binding	GTPase Activity G-protein Beta-subunit Binding
	Biological Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	G Protein-coupled Receptor Signaling Pathway Phototransduction
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Ranolazine Miconazole Carvedilol Dronedarone
Diseases
GWAS		Automobile speeding propensity ( 30643258) Chronotype ( 30696823) Conotruncal heart defects ( 24800985) TPE interval (resting) ( 32386560)	Asthma ( 31619474) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Metabolite levels ( 23823483) Prostate cancer ( 23535732) Refractive error ( 32231278) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		12 interacting genes: CASK DLG1 DLG2 DLG4 DPYD GNGT2 GPR35 IL16 KCNJ2 LIN7B PRKCD SNTA1	3 interacting genes: GNB4 KCNJ4 SRPK2
Entrez ID		3761	2793
HPRD ID		02738	06792
Ensembl ID		ENSG00000168135	ENSG00000167083
Uniprot IDs		A0A024R1L8 P48050 Q58F07	O14610
PDB IDs		3GJ9
Enriched GO Terms of Interacting Partners?
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