KCNJ3 and NFATC3

		KCNJ3	NFATC3
Description		potassium inwardly rectifying channel subfamily J member 3	nuclear factor of activated T cells 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex External Side Of Plasma Membrane T-tubule Parallel Fiber To Purkinje Cell Synapse Integral Component Of Presynaptic Membrane	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Response To Electrical Stimulus Regulation Of Heart Rate By Cardiac Conduction Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Import Across Plasma Membrane	Cytokine Production Regulation Of Transcription By RNA Polymerase II Inflammatory Response Calcineurin-NFAT Signaling Cascade Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation
Drugs		Atomoxetine Ethanol Halothane B-nonylglucoside Dronedarone Ifenprodil
Diseases
GWAS		Age at voice drop ( 27182965) Alcoholic chronic pancreatitis ( 28754779) Automobile speeding propensity ( 30643258) Dentures ( 31235808) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Feeling miserable ( 29500382) General cognitive ability ( 29844566) Leisure-time exercise behaviour ( 30102679) Leisure-time exercise behaviour (age-stratified) ( 30102679) Lung function (FEV1/FVC) ( 30061609) Metabolite levels ( 23823483) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 24871463)	Chronotype ( 30696823) Estimated glomerular filtration rate ( 31015462) Fasting glucose ( 33402679) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: GNB1 GPD2 KCNJ5 KCNJ6 KCNJ9 NFATC3	13 interacting genes: CALB2 CDK6 CELSR2 CSNK1A1 FOS KCNJ3 MAPK8 MAPK9 MYOCD SEC24A SNX20 TOR1B TTF1
Entrez ID		3760	4775
HPRD ID		03323	04077
Ensembl ID		ENSG00000162989	ENSG00000072736
Uniprot IDs		D2X9V0 D2XBF0 P48549	B5B2S0 B5B2S1 Q12968
PDB IDs			2XRW 2XS0
Enriched GO Terms of Interacting Partners?
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