KCNF1 and ALOX15B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KCNF1	ALOX15B
Description		potassium voltage-gated channel modifier subfamily F member 1	arachidonate 15-lipoxygenase type B
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane	Nucleus Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Membrane Extrinsic Component Of Membrane Extracellular Exosome
	Molecular Function	Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding	Iron Ion Binding Calcium Ion Binding Protein Binding Lipid Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Arachidonate 8(S)-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Linoleate 9S-lipoxygenase Activity
	Biological Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport	Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Negative Regulation Of Cell Migration Prostate Gland Development Regulation Of Epithelial Cell Differentiation Positive Regulation Of Chemokine Production Lipid Oxidation Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Linoleic Acid Metabolic Process Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Growth Hepoxilin Biosynthetic Process Endocannabinoid Signaling Pathway Cannabinoid Biosynthetic Process Lipoxin A4 Biosynthetic Process
Pathways		Voltage gated Potassium channels	Synthesis of 15-eicosatetraenoic acid derivatives
Drugs		Enflurane Promethazine Miconazole
Diseases
GWAS			Blood protein levels ( 30072576) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: ALOX15B CLPTM1L FARS2 KCNG3 KCNG4 KCNH1 KCNV2 MCL1 OPRM1 SERP1 SLC39A7 TCEA2 TSPO	9 interacting genes: CCDC115 CTAG1A CTAG1B KCNF1 PPARG RARA RXRA TRAIP TRIM21
Entrez ID		3754	247
HPRD ID		04808	04739
Ensembl ID		ENSG00000162975	ENSG00000179593
Uniprot IDs		Q9H3M0	O15296
PDB IDs			4NRE
Enriched GO Terms of Interacting Partners?
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