ASPG and GSDMD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ASPG	GSDMD
Description		asparaginase	gasdermin D
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region Extracellular Space Nucleoplasm Cytosol Plasma Membrane Integral Component Of Membrane Specific Granule Lumen NLRP3 Inflammasome Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Asparaginase Activity Lysophospholipase Activity Protein Binding Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Phosphatidyl Phospholipase B Activity	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Cardiolipin Binding
	Biological Process	Aspartate Family Amino Acid Metabolic Process Lipid Catabolic Process	Inflammatory Response Cellular Response To Extracellular Stimulus Positive Regulation Of Interleukin-1 Beta Production Pore Formation In Membrane Of Other Organism Defense Response To Bacterium Innate Immune Response Pore Complex Assembly Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Homooligomerization Pyroptosis
Pathways		Aspartate and asparagine metabolism	Release of apoptotic factors from the mitochondria Interleukin-1 processing Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Purinergic signaling in leishmaniasis infection
Drugs		Procaine
Diseases
GWAS		Blood metabolite levels ( 24816252) Body mass index ( 26426971) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free asparagine levels ( 30659259) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748)	Alanine aminotransferase levels ( 33547301) Monocyte count ( 32888494) Schizophrenia ( 31268507)
Interacting Genes		12 interacting genes: C20orf85 CEACAM6 DMRT3 GSDMD MYOZ3 RTP5 SGK1 SHC3 TEKT3 TMEM115 USP2 VPS25	8 interacting genes: ASPG KCTD6 MEOX2 MFHAS1 PSMA1 ZBTB33 ZNF426 ZNF558
Entrez ID		374569	79792
HPRD ID		19180	11014
Ensembl ID		ENSG00000166183	ENSG00000104518
Uniprot IDs		Q86U10	P57764
PDB IDs			5NH1 5WQT 6AO4 6KN0 6N9O
Enriched GO Terms of Interacting Partners?
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