KARS1 and SLC25A6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KARS1	SLC25A6
Description		lysyl-tRNA synthetase 1	solute carrier family 25 member 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex	Nucleus Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Membrane Integral Component Of Membrane
	Molecular Function	TRNA Binding ATP Adenylyltransferase Activity Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Identical Protein Binding Protein Homodimerization Activity	ATP:ADP Antiporter Activity Protein Binding
	Biological Process	Basophil Activation Involved In Immune Response Positive Regulation Of Inflammatory Response To Antigenic Stimulus Lysyl-tRNA Aminoacylation TRNA Processing Response To X-ray Diadenosine Tetraphosphate Biosynthetic Process Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade	Apoptotic Process Mitochondrial ADP Transmembrane Transport Mitochondrial ATP Transmembrane Transport
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	Mitochondrial protein import Mitochondrial protein import Influenza Virus Induced Apoptosis Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Drugs		L-Lysine	Clodronic acid Etidronic acid
Diseases
GWAS
Interacting Genes		85 interacting genes: AIMP2 CDC42 DARS2 DYSF EEF1D EEF1G ESR1 FRS3 GAPDH GEMIN4 LINC01554 MAPK1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-2 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 SPTAN1 SUMO2 VIM	20 interacting genes: AP2B1 CHEK2 CHGB DUX4 FGFR3 KARS1 KRT31 KRTAP4-12 LZTS2 MID2 MTUS2 NOTCH2NLA PLSCR1 PRSS23 STRN4 TEKT4 TRAF1 TRIM23 TRIP6 VIM
Entrez ID		3735	293
HPRD ID		03249	02461
Ensembl ID		ENSG00000065427	ENSG00000169100
Uniprot IDs		Q15046	P12236 Q6I9V5
PDB IDs		3BJU 4DPG 4YCU 4YCW 6CHD 6ILD 6ILH
Enriched GO Terms of Interacting Partners?
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