JAK3 and APOA1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		JAK3	APOA1
Description		Janus kinase 3	apolipoprotein A1
Image
GO Annotations	Cellular Component	Endosome Cytosol Cytoskeleton Plasma Membrane	Extracellular Region Extracellular Space Nucleus Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Endocytic Vesicle Cytoplasmic Vesicle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Extracellular Vesicle
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding	Amyloid-beta Binding Signaling Receptor Binding Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Chemorepellent Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	Adaptive Immune Response Negative Regulation Of Dendritic Cell Cytokine Production Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway B Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process T Cell Homeostasis Innate Immune Response Negative Regulation Of FasL Production Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of T Cell Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Response To Interleukin-9	Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Negative Regulation Of Cytokine Production Involved In Immune Response Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Nutrient Cholesterol Metabolic Process Glucocorticoid Metabolic Process Response To Xenobiotic Stimulus Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Esterification Positive Regulation Of Cholesterol Efflux Positive Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Peripheral Nervous System Axon Regeneration Protein Oxidation Peptidyl-methionine Modification Lipid Storage Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Animal Organ Regeneration Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Interleukin-1 Beta Production Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Response To Estrogen Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Protein Stabilization Negative Chemotaxis Positive Regulation Of Lipoprotein Lipase Activity Vitamin Transport Positive Regulation Of Hydrolase Activity Positive Regulation Of Stress Fiber Assembly Phospholipid Homeostasis Negative Regulation Of Lipase Activity Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Intermembrane Lipid Transfer Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phospholipid Efflux
Pathways		Interleukin-7 signaling Interleukin-7 signaling Signaling by ALK RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling Potential therapeutics for SARS	Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes TGD Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one R-348 Tofacitinib Baricitinib Fostamatinib Zanubrutinib	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Allergic rhinitis ( 30013184) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Body mass index ( 31978080) Cholesterol, total ( 24097068 19060911 20686565) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Delirium ( 29631748) Diastolic blood pressure ( 27841878) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 24097068 20864672 19060906 20686565 26582766) HDL cholesterol levels ( 28334899) Hearing function ( 25060954) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 27599772 23505323) Infantile hypertrophic pyloric stenosis ( 23989729) LDL cholesterol ( 24097068 18179892 20864672 19060911 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure ( 27841878) Total cholesterol levels ( 28334899 32759990) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 26763881 28371326 32759990 28548082) Triglycerides ( 24097068 19074352 21909109 18193043 18193044 18193046 20864672 19060906 19060911 20139978 20686565 26582766) Very low density lipoprotein cholesterol levels ( 28548082)
Interacting Genes		43 interacting genes: ALK APOA1 CD247 CD40 CD81 CDK1 CXCR4 ERBB3 FES GTF2B IKBKG IL2RB IL2RG IL4R IL7R INPP5D IRS1 IRS2 JAK1 JAK2 KHDRBS1 KIT LCK LNX1 PIK3R1 PRMT5 PTK2B PTPN2 PTPN6 PTPRC RAB8A SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT3 STAT5A STAT5B TIAF1 UHRF2 VIL1	37 interacting genes: ABCA1 ABCA13 AKT2 APOB APOC1 APOF APOL1 APP ATP5F1B BRAP CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR HSP90AA1 JAK3 LBP LCAT MAP7D1 NAXE NDRG1 PCMT1 PDE1A PLTP POLR1H PON1 SAA2 SCARB1 SPP1 TNFRSF10C TOMM20 TREM2 TTR VKORC1
Entrez ID		3718	335
HPRD ID		02547	02517
Ensembl ID		ENSG00000105639	ENSG00000118137
Uniprot IDs		A0A024R7M7 P52333	A0A024R3E3 P02647
PDB IDs		1YVJ 3LXK 3LXL 3PJC 3ZC6 3ZEP 4HVD 4HVG 4HVH 4HVI 4I6Q 4QPS 4QT1 4RIO 4V0G 4Z16 5LWM 5LWN 5TOZ 5TTS 5TTU 5TTV 5VO6 5W86 5WFJ 6AAK 6DA4 6DB3 6DB4 6DUD 6GL9 6GLA 6GLB 6HZV 6NY4 7APF 7APG 7C3N	1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2MSC 2MSD 2MSE 2N5E 3K2S 3R2P 4V6M 6CC9 6CCH 6CCX 6CLZ 6CM1 6PTS 6PTW 6W4E 6W4F 7KJR
Enriched GO Terms of Interacting Partners?
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