JAK1 and DAB1

JAK1

DAB1

Description Janus kinase 1 DAB adaptor protein 1
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • 3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134)
  • Age at first sexual intercourse ( 34211149)
  • Alzheimer's disease progression score ( 29860282)
  • Brain morphology (min-P) ( 32665545)
  • Brain morphology (MOSTest) ( 32665545)
  • Bulimia nervosa ( 23568457)
  • Cardiac troponin-I levels ( 31014085)
  • Coronary artery disease ( 29472232)
  • Cortical surface area (min-P) ( 32665545)
  • Cortical surface area (MOSTest) ( 32665545)
  • Cortical thickness (min-P) ( 32665545)
  • Cortical thickness (MOSTest) ( 32665545)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • Household income (MTAG) ( 31844048)
  • Immune reponse to smallpox (secreted IL-10) ( 22610502)
  • Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566)
  • Insomnia symptoms (never/rarely vs. usually) ( 30804566)
  • Kawasaki disease ( 21221998)
  • Lateral orbital frontal cortex volume ( 31530798)
  • Logical memory (delayed recall) in normal cognition ( 29274321)
  • Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457)
  • Pubertal anthropometrics ( 23449627)
  • Risk-taking tendency (4-domain principal component model) ( 30643258)
  • Serum linoleic acid concentration in metabolic syndrome ( 31991592)
  • Subcortical volume (min-P) ( 32665545)
  • Subcortical volume (MOSTest) ( 32665545)
  • Waist circumference ( 28552196)
  • White matter hyperintensities in ischemic stroke ( 26674333)
Interacting Genes 81 interacting genes: ABL1 AGTR1 ANKRD13C BRCA1 BTK CBR1 CCR1 CCR5 CSF2RB CSF3R CXCR4 DAB1 DHX9 EIF2AK2 ELP2 ERBB2 FER FES GAB1 GHR GRB2 H3-4 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK2 JAK3 JAKMIP1 MDK NFYC OSMR P2RY1 P3H1 PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RACK1 RAF1 SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 SYK TEC TNFRSF1A TOP1 TSHR TYK2 USP6 VNN2 78 interacting genes: APLP1 APLP2 APP ARID5A BHLHE40 C1orf94 CDK5 CIART CLASRP CRK CRKL DAB2IP DAZAP2 ERBB2 ERBB3 FAM168A HMBOX1 HNRNPLL HYAL3 INPP5D ITGB2 ITGB3 ITGB5 ITGB7 ITSN1 JAK1 JUN KRTAP19-5 KRTAP19-7 KRTAP8-1 LDLR LGALS9B LGALS9C LNX1 LRP1 LRP2 LRP8 MAGED1 MAPK14 MBNL1 MBNL3 MYO6 NAF1 NTAQ1 PAFAH1B1 PCDH18 PIN1 PLCG1 POGZ PPIG PRR20A PTPN11 RAMAC RBFOX1 RBFOX2 RELN RHOXF2 ROR2 SERF2 SIAH1 SIRPB1 SMAP2 SNRPB SOCS6 SOCS7 SRC STRBP TCEA2 TCEANC TMTC3 TOLLIP USP53 VENTX VLDLR ZBTB32 ZC3H10 ZCCHC10 ZNF488
Entrez ID 3716 1600
HPRD ID 00992 04582
Ensembl ID ENSG00000162434 ENSG00000173406
Uniprot IDs P23458 Q6P669 O75553
PDB IDs 3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 5E1E 5HX8 5IXD 5IXI 5KHW 5KHX 5L04 5WO4 6AAH 6BBU 6C7Y 6DBN 6ELR 6GGH 6HZU 6N77 6N78 6N79 6N7A 6N7B 6N7C 6N7D 6RSB 6RSC 6RSD 6RSE 6RSH 6SM8 6SMB 6TPE 6TPF 6W8L
Enriched GO Terms of Interacting Partners?
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