JAG2 and NOTCH3

Number of citations of the paper that reports this interaction (PubMedID 11006133)
27

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		JAG2	NOTCH3
Description		jagged canonical Notch ligand 2	notch receptor 3
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Golgi Membrane Extracellular Region Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Receptor Complex
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding Growth Factor Activity	Calcium Ion Binding Protein Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding
	Biological Process	Skeletal System Development In Utero Embryonic Development Respiratory System Process Notch Signaling Pathway Spermatogenesis Auditory Receptor Cell Fate Commitment Morphogenesis Of Embryonic Epithelium Cell Differentiation Regulation Of Cell Adhesion T Cell Differentiation Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Gamma-delta T Cell Differentiation Thymic T Cell Selection Positive Regulation Of Notch Signaling Pathway Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis	Regulation Of Transcription, DNA-templated Notch Signaling Pathway Axon Guidance Regulation Of Developmental Process
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Fasting plasma glucose ( 31932636) Red blood cell count ( 32888494)	Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)
Interacting Genes		13 interacting genes: ATN1 ATXN7 CACNA1A CKB GFI1B HOXA1 KLC1 MBD1 MIB2 NOTCH1 NOTCH2 NOTCH3 SHANK3	54 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 HOXA1 JAG1 JAG2 KAT2B LINC00839 LTBP1 MAML1 MAML2 MAML3 MBD1 MPPED2 MTDH MYC NEDD9 NUFIP2 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SHANK3 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 UPF1 WDR25 XKR8
Entrez ID		3714	4854
HPRD ID		03981	02607
Ensembl ID		ENSG00000184916	ENSG00000074181
Uniprot IDs		Q9Y219	Q9UM47
PDB IDs		5MW5 5MW7 5MWF	4ZLP 5CZV 5CZX
Enriched GO Terms of Interacting Partners?
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