IRF4 and FLRT3

		IRF4	FLRT3
Description		interferon regulatory factor 4	fibronectin leucine rich transmembrane protein 3
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GO Annotations	Cellular Component	Chromatin Nucleosome Nucleus Nucleoplasm Cytosol Membrane	Extracellular Space Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Cell Junction Extracellular Matrix Growth Cone Membrane Axon Terminus Axonal Growth Cone Synaptic Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Protein Homodimerization Activity Chemorepellent Activity
	Biological Process	Immune System Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Binding Histone H3 Acetylation Histone H4 Acetylation Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T-helper 17 Cell Lineage Commitment Positive Regulation Of Cold-induced Thermogenesis	Proepicardium Cell Migration Involved In Pericardium Morphogenesis Axon Guidance Synapse Assembly Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Neuron Projection Development Embryonic Morphogenesis Response To Axon Injury Negative Chemotaxis Positive Regulation Of Synapse Assembly Head Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Synaptic Membrane Adhesion Neuron Projection Extension
Pathways		Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling	Signaling by ROBO receptors Downstream signaling of activated FGFR1
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basal cell carcinoma ( 31174203 27539887) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Celiac disease ( 22057235 20190752) Chronic lymphocytic leukemia ( 18758461 28165464 26956414 24292274 23770605) Crohn's disease ( 26192919) Cutaneous squamous cell carcinoma ( 27424798 32041948) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Epstein-Barr virus EA-D antibody levels ( 33204752) Eye color ( 20585627 33692100 30664655) Eye color (brightness) ( 30664655) Eye color traits ( 30166351) Facial pigmentation ( 25705849) Feeling nervous ( 29500382) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627 30664655 29662168 26926045) Hair greying ( 26926045) Hair morphology traits ( 30166351) Hematology traits ( 23303382) IgA nephropathy ( 32912934) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Limited cutaneous systemic scleroderma ( 29293537) Low tan response ( 29739929) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 29146897 27182965 28196072) Medication use (thyroid preparations) ( 31015401) Melanoma ( 28212542) Membranous nephropathy ( 32231244) Monobrow ( 27182965) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Non-melanoma skin cancer ( 23548203 29739929) Progressive supranuclear palsy ( 21685912) Psoriasis ( 25903422 25574825 23143594) Rheumatoid arthritis ( 30423114 24390342) Rosacea symptom severity ( 29771307) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Systemic lupus erythematosus ( 33536424) Tanning ( 23548203) Type 1 diabetes ( 34012112 34127860) Vitiligo ( 27723757) White blood cell count ( 32888494) Youthful appearance (self-reported) ( 32339537)	Bipolar disorder ( 33169155) Blood protein levels ( 30072576 29875488) Mood disorder in prion disease ( 25897833)
Interacting Genes		28 interacting genes: BATF BCL6 CUTA ELP1 ETV7 FKBP4 FLRT3 GIPC2 HOXB13 HOXC11 HPSE INSL4 IRAK1 MYD88 NEDD9 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TBCC TLK2 TOP1 TRAF2 TSEN54 USP4 YTHDC2	3 interacting genes: FGFR1 IRF4 UNC5B
Entrez ID		3662	23767
HPRD ID		03543	05313
Ensembl ID		ENSG00000137265	ENSG00000125848
Uniprot IDs		Q15306	Q9NZU0
PDB IDs		2DLL	5CMN 5CMP 6JBU
Enriched GO Terms of Interacting Partners?
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