INSRR and STYX

Number of citations of the paper that reports this interaction (PubMedID 28065597)
37

Data Source:
BioGRID (two hybrid)

		INSRR	STYX
Description		insulin receptor related receptor	serine/threonine/tyrosine interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Insulin Receptor Complex Axon Receptor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Protein Binding ATP Binding Phosphatidylinositol 3-kinase Binding Insulin Receptor Substrate Binding	Pseudophosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity F-box Domain Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Male Sex Determination Actin Cytoskeleton Reorganization Positive Regulation Of Kinase Activity Protein Autophosphorylation Cellular Response To Alkaline PH	Protein Dephosphorylation Negative Regulation Of Protein Binding Negative Regulation Of Catalytic Activity MAPK Export From Nucleus Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Regulation Of ERK1 And ERK2 Cascade
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Uric acid clearance ( 28095793)	Prostate cancer ( 23535732)
Interacting Genes		6 interacting genes: CTDSP2 ERBB2 INSR KRT27 MEOX2 STYX	24 interacting genes: AATK CARHSP1 EGFR EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 FBXO7 FBXW7 IGF1R INSR INSRR KDR KIT LMTK2 MAPK1 MUSK PTK7 ROR1 ROR2 TEK
Entrez ID		3645	6815
HPRD ID		00976	10258
Ensembl ID		ENSG00000027644	ENSG00000198252
Uniprot IDs		P14616	A0A024R641 Q8WUJ0
PDB IDs			2R0B
Enriched GO Terms of Interacting Partners?
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