INSL3 and RXFP2

Number of citations of the paper that reports this interaction (PubMedID 12114498)
68

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		INSL3	RXFP2
Description		insulin like 3	relaxin family peptide receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding Protease Binding Signaling Receptor Binding Insulin Receptor Binding Hormone Activity Protein Binding	G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Peptide Hormone Binding
	Biological Process	Oocyte Maturation Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Spermatogenesis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Apoptotic Process Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Wound Healing	Oocyte Maturation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Male Gonad Development Hormone-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of CAMP-mediated Signaling
Pathways		G alpha (s) signalling events Relaxin receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Relaxin receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS			Essential hypertension (time to event) ( 32589924) Glycated hemoglobin levels in type 1 diabetes ( 30674623) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 30578418) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		3 interacting genes: C12orf57 RBPJ RXFP2	2 interacting genes: INSL3 RLN2
Entrez ID		3640	122042
HPRD ID		08854	05976
Ensembl ID		ENSG00000248099	ENSG00000133105
Uniprot IDs		P51460	Q8WXD0
PDB IDs		2H8B 2K6T 2K6U	2M96
Enriched GO Terms of Interacting Partners?
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