IL12RB1 and STAT4

Number of citations of the paper that reports this interaction (PubMedID 10415122)
12

Data Source:
HPRD (in vivo)

		IL12RB1	STAT4
Description		interleukin 12 receptor subunit beta 1	signal transducer and activator of transcription 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex	Chromatin Nucleoplasm Cytosol
	Molecular Function	Cytokine Receptor Activity Interleukin-12 Receptor Binding Interleukin-12 Receptor Activity Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Cellular Response To Interferon-gamma Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Regulation Of Transcription By RNA Polymerase II Defense Response Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling	Interleukin-20 family signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-21 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Mental health study participation (completed survey) ( 31263887) Pulmonary function in asthmatics ( 23541324) Systemic sclerosis ( 31672989 30572963) Waist circumference adjusted for body mass index ( 34021172)	Arthritis (juvenile idiopathic) ( 33106285) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 23001997 23291587) Celiac disease ( 22057235 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil counts ( 32888494) Gamma glutamyl transferase levels ( 29403010) Generalized epilepsy ( 30531953) Hepatocellular carcinoma in hepatitis B infection ( 23242368) Idiopathic inflammatory myopathy ( 26362759) Inflammatory bowel disease ( 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Limited cutaneous systemic scleroderma ( 29293537) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Nontyphoidal Salmonella bacteraemia ( 29523850) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 32723749 30423114 30572963 23143596 24390342 20453841 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) SjÃ¶gren's syndrome ( 24097066 24097067 28076899) Systemic lupus erythematosus ( 27399966 24871463 26606652 23273568 33272962 26663301 23053960 26316170 26502338 18204098 21408207 32771030 19165918 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 28314753 24387989 21750679 31672989 33069728 30572963 20383147 29293537 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)
Interacting Genes		7 interacting genes: BRD4 IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4	24 interacting genes: ADRB2 CADM3 CCDC85A CLPP CREBBP CRK DNAH7 HNRNPCP2 IL12RB1 IL12RB2 JUN LY86 MAP2K6 MAPK14 NABP1 NEMP2 NMI PIAS2 PTMS SH2D1B STAT1 STAT3 TMEFF2 ZNF467
Entrez ID		3594	6775
HPRD ID		03363	02779
Ensembl ID		ENSG00000096996	ENSG00000138378
Uniprot IDs		P42701	Q14765
PDB IDs		6WDP 6WDQ
Enriched GO Terms of Interacting Partners?
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