CXCR2 and GNAI2

Number of citations of the paper that reports this interaction (PubMedID 8662698)
11

Data Source:
HPRD (in vivo)

		CXCR2	GNAI2
Description		C-X-C motif chemokine receptor 2	G protein subunit alpha i2
Image
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Midbody Cell Body Membrane Raft Synapse Extracellular Exosome Extracellular Vesicle
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Calcium-mediated Signaling Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis	G Protein-coupled Adenosine Receptor Signaling Pathway Cell Cycle Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Protein Tyrosine Phosphatase Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		32 interacting genes: ADRA1A ARRB1 ATP13A1 C4orf3 CLDN22 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 EMP1 FKBP8 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 SLC18A2 SLC39A2 SMCO4 ST13 TMEM147 TMEM80 TRARG1	67 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR1 CCR5 CHRM1 CNR1 CTNNB1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LAG3 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A
Entrez ID		3579	2771
HPRD ID		00907	00764
Ensembl ID		ENSG00000180871	ENSG00000114353
Uniprot IDs		P25025 Q53PC4	B3KP24 B3KX51 P04899
PDB IDs		4Q3H 5TYT 6KVA 6KVF 6LFM 6LFO	6D9H
Enriched GO Terms of Interacting Partners?
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