IL6R and PEX1

		IL6R	PEX1
Description		interleukin 6 receptor	peroxisomal biogenesis factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Interleukin-6 Receptor Complex External Side Of Plasma Membrane Apical Plasma Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex	Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Extracellular Exosome
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Interleukin-6 Receptor Binding Protein Binding Enzyme Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Ciliary Neurotrophic Factor Binding	Protein Binding ATP Binding Protein C-terminus Binding ATP Hydrolysis Activity Protein-containing Complex Binding
	Biological Process	Hepatic Immune Response Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Activation Of Janus Kinase Activity Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Response To Cytokine Interleukin-11-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Interleukin-6-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Glomerular Mesangial Cell Proliferation T-helper 17 Cell Lineage Commitment Extrinsic Apoptotic Signaling Pathway	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Microtubule-based Peroxisome Localization
Pathways		Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Interleukin-4 and Interleukin-13 signaling Transcriptional regulation of granulopoiesis Potential therapeutics for SARS	Peroxisomal protein import Peroxisomal protein import
Drugs		Tocilizumab Sarilumab Satralizumab
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187) Asthma ( 32296059 21907864) Atopic dermatitis ( 26482879) Atrial fibrillation ( 29892015) Blood protein levels ( 30072576 29875488 28240269 23696881) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein ( 19567438 18439548) C-reactive protein levels ( 29403010 33339817 30388399 21300955) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Fibrinogen ( 20031577 23969696) Fibrinogen levels ( 28107422 26561523) Interleukin-6 levels ( 33517400 32473944) Interleukin-6 levels in HIV infection ( 33095540) Iron status biomarkers (iron levels) ( 33536631) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Myocardial infarction ( 33532862 26343387) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Platelet count ( 32888494) Protein quantitative trait loci ( 18464913) Pulmonary function ( 17903307) Red cell distribution width ( 32888494) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 34127860)	Height ( 18391951) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		15 interacting genes: ADRB2 CNTF ERAP1 IL6 IL6ST IVL MAGI1 MCL1 PEX1 SGTB SLC39A2 SRC STAT3 WWP1 WWP2	4 interacting genes: IL6R PEX26 PEX5 PEX6
Entrez ID		3570	5189
HPRD ID		01000	03682
Ensembl ID		ENSG00000160712	ENSG00000127980
Uniprot IDs		A0A087WTB5 A0N0L5 P08887	A0A0C4DG33 B4DER6 O43933
PDB IDs		1N26 1N2Q 1P9M 2ARW 5FUC 7DC8
Enriched GO Terms of Interacting Partners?
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