IL4 and HSPA9

		IL4	HSPA9
Description		interleukin 4	heat shock protein family A (Hsp70) member 9
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	SAM Complex Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Focal Adhesion Mitochondrial Nucleoid Extracellular Exosome MIB Complex
	Molecular Function	Cytokine Activity Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity	RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Innate Immune Response In Mucosa Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Chronic Inflammatory Response Immune Response Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Macroautophagy B Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation B Cell Costimulation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Type 2 Immune Response Positive Regulation Of T Cell Proliferation T Cell Activation Macrophage Activation Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Myeloid Dendritic Cell Differentiation Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of Mast Cell Degranulation T-helper 2 Cell Differentiation Regulation Of Isotype Switching Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Mononuclear Cell Migration Dendritic Cell Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cold-induced Thermogenesis Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Myoblast Fusion Positive Regulation Of Cellular Respiration Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Eosinophil Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Export From Nucleus Inner Mitochondrial Membrane Organization Iron-sulfur Cluster Assembly Erythrocyte Differentiation Cellular Response To Unfolded Protein Protein Refolding Negative Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Hemopoiesis
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling	Mitochondrial protein import Regulation of HSF1-mediated heat shock response Cristae formation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Pascolizumab
Diseases
GWAS		Asthma ( 31959851 31619474 29273806) Asthma (childhood onset) ( 31036433 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825) Atopic march ( 26542096) Inflammatory bowel disease ( 23128233) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278)	Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 25056061 29483656)
Interacting Genes		8 interacting genes: A2M CD53 FBXO7 HSPA9 IL13RA2 IL2RG IL4R PIK3CD	32 interacting genes: APP DNAJC19 DNLZ ERBB2 ERCC6 FGF1 GDF9 HSP90B1 HSPBP1 IL3 IL4 IL5 IL9 LAMTOR5 LINC01554 LSM8 MATK MVD NELFB OGT PTPN11 PTPRF SIRPA STUB1 SUMO2 SUMO4 SUPT6H TIMM44 TP53 XPO1 YKT6 YWHAG
Entrez ID		3565	3313
HPRD ID		00989	02770
Ensembl ID		ENSG00000113520	ENSG00000113013
Uniprot IDs		D4HNR6 P05112 Q5FC01	A0A384P5G6 P38646
PDB IDs		1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL	3N8E 4KBO 6NHK 6P2U 6PMT
Enriched GO Terms of Interacting Partners?
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