IL3RA and CSF2

Number of citations of the paper that reports this interaction (PubMedID 7957082)
20

Data Source:
HPRD (in vitro)

		IL3RA	CSF2
Description		interleukin 3 receptor subunit alpha	colony stimulating factor 2
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space Intracellular Membrane-bounded Organelle
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway	Histamine Secretion Embryonic Placenta Development Immune Response Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Myeloid Cell Differentiation Neutrophil Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Interleukin-23 Production Response To Silicon Dioxide Response To Fluid Shear Stress Epithelial Fluid Transport Macrophage Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Myeloid Dendritic Cell Differentiation Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling
Drugs		Sargramostim Tagraxofusp	KB002
Diseases
GWAS		Schizophrenia ( 17522711)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Rheumatoid arthritis ( 30423114 22446963 24390342) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5	15 interacting genes: CSF2RA CSF2RB DPP7 ETF1 FBN2 IKBKE IL3RA KITLG MEOX2 P2RX7 PRG2 SDC2 SEMA7A TAGLN TREML2
Entrez ID		3563	1437
HPRD ID		02392	00734
Ensembl ID		ENSG00000185291	ENSG00000164400
Uniprot IDs		P26951	P04141
PDB IDs		4JZJ 5UV8 5UWC 6NMY	1CSG 2GMF 4NKQ 4RS1 5C7X 5D70 5D71 5D72 6BFQ 6BFS
Enriched GO Terms of Interacting Partners?
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