IL3 and CSF2RB

Number of citations of the paper that reports this interaction (PubMedID 9278420)
6

Data Source:
HPRD (in vivo, in vitro)

		IL3	CSF2RB
Description		interleukin 3	colony stimulating factor 2 receptor subunit beta
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-3 Receptor Binding Growth Factor Activity	Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Immune Response Signal Transduction Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Embryonic Hemopoiesis Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Peptidyl-tyrosine Phosphorylation	Signal Transduction Respiratory Gaseous Exchange By Respiratory System Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade RUNX1 regulates transcription of genes involved in interleukin signaling Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling
Drugs		Amlexanox Zinc Polaprezinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Sargramostim NPI 32101 Resatorvid
Diseases
GWAS		Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388 21102463) Inflammatory bowel disease ( 28067908 23128233) Perceived unattractiveness to mosquitoes ( 28199695) Rheumatoid arthritis ( 30423114 24390342) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576 29875488) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Perceived unattractiveness to mosquitoes ( 28199695)
Interacting Genes		10 interacting genes: BRD8 CSF2RB HRAS HSPA1A HSPA9 IL3RA IRF1 PIK3CA PIK3CD PPP2CA	27 interacting genes: CISH CSF2 CSF2RA EPOR FES FYN HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 RACK1 SHC1 STAT1 STAT3 SYK YWHAZ
Entrez ID		3562	1439
HPRD ID		00987	00739
Ensembl ID		ENSG00000164399	ENSG00000100368
Uniprot IDs		P08700	P32927 Q6NSJ8
PDB IDs		1JLI 5UV8 5UWC 6NMY	1C8P 1EGJ 1GH7 2GYS 2NA8 2NA9 4NKQ 5DWU
Enriched GO Terms of Interacting Partners?
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