IL1RN and COPS4

Number of citations of the paper that reports this interaction (PubMedID 15749898)
15

Data Source:
BioGRID (pull down)

		IL1RN	COPS4
Description		interleukin 1 receptor antagonist	COP9 signalosome subunit 4
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytosol Synaptic Vesicle COP9 Signalosome Nuclear Speck Cell Junction
	Molecular Function	Cytokine Activity Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity	Protein Binding NEDD8-specific Protease Activity
	Biological Process	Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Inflammatory Response Immune Response Signal Transduction Insulin Secretion Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Glucocorticoid Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Protein Deneddylation
Pathways		Interleukin-10 signaling Interleukin-1 signaling	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
Drugs		Rilonacept
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576 29875488) C-reactive protein ( 22939635) C-reactive protein levels ( 33339817) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Interleukin-6 levels ( 33517400) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Stroke ( 26089329) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)	Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: COPS3 COPS4 IL1R1 IL1R2 POT1 TERF2IP	24 interacting genes: BRME1 CCDC85B COPS2 COPS3 COPS5 COPS6 COPS7A COPS7B COPS8 CUL5 FOS GPS1 IKBKB IL1RN KRT19 MBIP PCDHB12 PEX14 RBX1 RCBTB2 TP53 UBQLN1 USHBP1 YWHAQ
Entrez ID		3557	51138
HPRD ID		00978	09888
Ensembl ID		ENSG00000136689	ENSG00000138663
Uniprot IDs		A0A024R528 P18510	A0A0S2Z5H7 B3KM48 D6RAX7 Q9BT78
PDB IDs		1ILR 1ILT 1IRA 1IRP 1ITN 2IRT	4D0P 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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