IL1R1 and SIGIRR

Number of citations of the paper that reports this interaction (PubMedID 12925853)
169

Data Source:
HPRD (in vivo)

		IL1R1	SIGIRR
Description		interleukin 1 receptor type 1	single Ig and TIR domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protease Binding Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Interleukin-1 Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	NAD+ Nucleosidase Activity Protein Binding
	Biological Process	Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Neutrophil Extravasation Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Interleukin-1-mediated Signaling Pathway	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of DNA-binding Transcription Factor Activity
Pathways		Interleukin-10 signaling Interleukin-1 signaling Potential therapeutics for SARS	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling
Drugs		Anakinra SD118 OMS-103HP Foreskin fibroblast (neonatal)
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Alanine aminotransferase levels ( 33547301) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Ankylosing spondylitis ( 23749187) Asthma ( 31959851 30929738 31619474 29785011 22561531) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 30072576 28240269) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Apolipoprotein A1 levels ( 32203549) Lymphocyte counts ( 32888494)
Interacting Genes		12 interacting genes: HYOU1 IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP	9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6
Entrez ID		3554	59307
HPRD ID		00994	12018
Ensembl ID		ENSG00000115594	ENSG00000185187
Uniprot IDs		B8ZZW4 P14778	C9JFX4 Q6IA17
PDB IDs		1G0Y 1IRA 1ITB 4DEP 4GAF
Enriched GO Terms of Interacting Partners?
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