TICAM2 and LVRN

		TICAM2	LVRN
Description		toll like receptor adaptor molecule 2	laeverin
Image			No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Endosome Membrane COPII-coated ER To Golgi Transport Vesicle Secretory Granule Membrane Early Endosome Membrane Late Endosome Membrane Cell Projection	Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	NAD+ Nucleosidase Activity Protein Binding	Zinc Ion Binding Peptide Binding Metalloaminopeptidase Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phagocytosis Inflammatory Response Golgi Organization Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Cellular Response To Lipopolysaccharide Positive Regulation Of Interleukin-18-mediated Signaling Pathway	Proteolysis Signal Transduction Regulation Of Blood Pressure Peptide Catabolic Process
Pathways		Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF-mediated programmed cell death Neutrophil degranulation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Response to antidepressants (symptom improvement) ( 29160301)	Spontaneous preterm birth without premature rupture of membranes ( 31194736)
Interacting Genes		21 interacting genes: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 LVRN MEF2C MEOX2 NTAQ1 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6	10 interacting genes: COMMD10 DTWD2 FAM170A IFIT3 LMNA PRR16 SEMA6A SRFBP1 TICAM2 TNFAIP8
Entrez ID		353376	206338
HPRD ID		16313	07118
Ensembl ID		ENSG00000243414	ENSG00000172901
Uniprot IDs		Q86XR7	Q0P5U8 Q6Q4G3
PDB IDs		2M1W
Enriched GO Terms of Interacting Partners?
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