LCE2C and CYP21A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LCE2C	CYP21A2
Description		late cornified envelope 2C	cytochrome P450 family 21 subfamily A member 2
Image		No pdb structure
GO Annotations	Cellular Component		Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Steroid 21-monooxygenase Activity Steroid Binding Iron Ion Binding Steroid Hydroxylase Activity Heme Binding 17-hydroxyprogesterone 21-hydroxylase Activity Progesterone 21-hydroxylase Activity
	Biological Process	Keratinization	Steroid Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Steroid Metabolic Process Sterol Metabolic Process
Pathways		Formation of the cornified envelope	Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP21A2 causes AH3
Drugs			Ketoconazole
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Clostridioides difficle infection ( 33841421) Diastolic blood pressure ( 25249183) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 25249183) Inflammatory bowel disease ( 28067908) Postoperative atrial fibrillation in coronary artery bypass grafting surgery ( 26385043) Prostate cancer ( 23535732) Systolic blood pressure ( 25249183) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		84 interacting genes: ADAMTSL4 ALPP C1orf94 CATSPER1 CCDC125 CHIC2 CRCT1 CREB5 CYP21A2 CYSRT1 EFEMP1 EFEMP2 EFNA3 FAM221B HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2D LCE3A LCE3B LCE3D LCE4A LCE5A MACO1 NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 OTX1 PCSK5 PIAS2 PTPMT1 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRY1 TAP1 TGFB1 TM7SF2 TRIM42 UBE2I VASN VWC2 XAGE3	18 interacting genes: CRCT1 CREB5 CYSRT1 HOXA1 KRTAP1-3 KRTAP4-2 KRTAP9-2 LCE1F LCE2C LCE3B LCE3C LCE5A NBPF19 NOTCH2NLA NR4A3 PICK1 POTEB3 POU4F2
Entrez ID		353140	1589
HPRD ID		13972	01942
Ensembl ID		ENSG00000187180	ENSG00000231852
Uniprot IDs		Q5TA81	P08686 Q08AG9 Q16874
PDB IDs			2GEG 4Y8W 5VBU
Enriched GO Terms of Interacting Partners?
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