RBPJ and SEL1L3

		RBPJ	SEL1L3
Description		recombination signal binding protein for immunoglobulin kappa J region	SEL1L family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Transcription Repressor Complex	Nucleoplasm Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein N-terminus Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Somitogenesis Epithelial To Mesenchymal Transition Blood Vessel Remodeling Inflammatory Response To Antigenic Stimulus Secondary Heart Field Specification Outflow Tract Morphogenesis Endocardium Morphogenesis Aortic Valve Development Pulmonary Valve Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Left Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Humoral Immune Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Negative Regulation Of Cell Population Proliferation Auditory Receptor Cell Fate Commitment Epidermal Cell Fate Specification Positive Regulation Of Gene Expression Pituitary Gland Development B Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Ossification Positive Regulation Of BMP Signaling Pathway Somatic Stem Cell Population Maintenance Dorsal Aorta Morphogenesis Atrioventricular Canal Development Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Timing Of Cell Differentiation Sebaceous Gland Development Hair Follicle Maturation Positive Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Club Cell Differentiation Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Fate Commitment Notch Signaling Involved In Heart Development Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Blood Vessel Lumenization Blood Vessel Endothelial Cell Fate Specification Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Ephrin Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Autoimmune traits (pleiotropy) ( 30572963) Body shape index ( 34021172) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494) Rheumatoid arthritis ( 24449572 23143596 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Takayasu arteritis ( 33308445) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Systolic blood pressure ( 28234671)
Interacting Genes		36 interacting genes: APP ART3 CCKAR CCNF CIR1 FHL1 GADD45A GSK3B HDAC1 HMGB1 HSPB1 INSL3 KAT2A KAT2B MAML1 MED27 NCOR1 NCOR2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PTF1A RPS6KA6 RSC1A1 SEL1L3 SIN3A SND1 SNW1 SPEN SPOP SPTB SUFU TP53 ZCCHC4 ZDHHC7	3 interacting genes: RBPJ SLIT2 TUBB3
Entrez ID		3516	23231
HPRD ID		00920	11105
Ensembl ID		ENSG00000168214	ENSG00000091490
Uniprot IDs		Q06330	A0A024R9V3 Q68CR1
PDB IDs		2F8X 3NBN 3V79 6PY8
Enriched GO Terms of Interacting Partners?
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