IFNAR1 and IFNA1

Number of citations of the paper that reports this interaction (PubMedID 7932753)
38

Data Source:
HPRD (in vitro)

		IFNAR1	IFNA1
Description		interferon alpha and beta receptor subunit 1	interferon alpha 1
Image
GO Annotations	Cellular Component	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding	Cytokine Activity Type I Interferon Receptor Binding Protein Binding
	Biological Process	Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway Positive Regulation Of Cellular Respiration	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Response To Exogenous DsRNA Defense Response To Virus
Pathways		Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS	Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Human interferon beta
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		26 interacting genes: BRCC3 CRKL FBXW11 GART IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70	5 interacting genes: CR2 GLDC IFNAR1 IL2 IRF9
Entrez ID		3454	3439
HPRD ID		00126	00974
Ensembl ID		ENSG00000142166	ENSG00000197919
Uniprot IDs		A0A494C0E2 P17181	L0N195 P01562
PDB IDs		3S98 3SE3 3SE4 4PO6	3UX9
Enriched GO Terms of Interacting Partners?
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