IDH2 and FURIN

IDH2

FURIN

Description isocitrate dehydrogenase (NADP(+)) 2 furin, paired basic amino acid cleaving enzyme
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Age at first sexual intercourse ( 27089180 34211149)
  • Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081)
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Apolipoprotein A1 levels ( 32203549)
  • Asthma ( 32296059)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Birth weight ( 31043758)
  • Brain morphology (MOSTest) ( 32665545)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Coronary artery disease ( 32469254 29212778 26343387)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Daytime sleep phenotypes ( 27126917)
  • Diastolic blood pressure ( 21909115 28739976 27618452)
  • Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • General risk tolerance (MTAG) ( 30643258)
  • Hypertension ( 21909115 30487518)
  • Ischemic stroke ( 29531354)
  • Left-handedness ( 32989287)
  • Mean arterial pressure ( 27618448 30487518)
  • Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Myocardial infarction ( 26343387)
  • Neutrophil count ( 32888494)
  • Offspring birth weight ( 31043758)
  • Parental lifespan ( 30642433)
  • Parental longevity (combined parental age at death) ( 29227965)
  • Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
  • Parental longevity (father's attained age) ( 29227965)
  • Risk-taking tendency (4-domain principal component model) ( 30643258)
  • Schizophrenia ( 25056061 29483656 30285260)
  • Stroke ( 29531354)
  • Systolic blood pressure ( 26390057 28135244 21909115 29403010 28739976 27618452)
  • Systolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • White blood cell count ( 32888494)
Interacting Genes 6 interacting genes: ACAN FBXO7 FURIN GPX1 PYGL SLC2A4 38 interacting genes: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 ASH2L BACE1 CNMD COL23A1 DSG3 EDA FES FGF2 FLNA FLNC IDH2 IL1B ITM2C LRP1 MMP14 NAGPA NOTCH1 NPC1 NUCB2 PACS1 PDE4D PDGFA PELO PMCH PRB4 SERPINB8 SORCS1 SORL1 TMOD3 TNFSF13 VWF ZP3 ZP4
Entrez ID 3418 5045
HPRD ID 00973 00653
Ensembl ID ENSG00000182054 ENSG00000140564
Uniprot IDs B4DSZ6 P48735 A0A024RC70 P09958
PDB IDs 4JA8 5GIS 5I95 5I96 5SVN 5SVO 6ADI 6VFZ 4OMC 4OMD 4RYD 4Z2A 5JMO 5JXG 5JXH 5JXI 5JXJ 5MIM 6A8Y 6EQV 6EQW 6EQX 6HLB 6HLD 6HLE 6HZA 6HZB 6HZC 6HZD 6YD2 6YD3 6YD4 6YD7
Enriched GO Terms of Interacting Partners?
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