ICAM1 and KIF1A

		ICAM1	KIF1A
Description		intercellular adhesion molecule 1	kinesin family member 1A
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome	Cytosol Kinesin Complex Microtubule Synaptic Vesicle Axon Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extrinsic Component Of Neuronal Dense Core Vesicle Membrane Postsynapse Neuronal Dense Core Vesicle Axon Cytoplasm
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity	Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Identical Protein Binding
	Biological Process	Ovarian Follicle Development Regulation Of Leukocyte Mediated Cytotoxicity Response To Amphetamine T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Acute Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Aging Sensory Perception Of Sound Regulation Of Cell Shape Response To Xenobiotic Stimulus Response To Ionizing Radiation Response To Sulfur Dioxide Membrane To Membrane Docking Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels Response To Insulin Cell Adhesion Mediated By Integrin Response To Gonadotropin Response To Amino Acid Positive Regulation Of GTPase Activity Adhesion Of Symbiont To Host Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Positive Regulation Of Vasoconstriction Response To Copper Ion Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Calcium Ion Transport Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Alkaloid Cellular Response To Glucose Stimulus Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus T Cell Extravasation Establishment Of Endothelial Intestinal Barrier Establishment Of Sertoli Cell Barrier Regulation Of Ruffle Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process	Microtubule-based Movement Anterograde Axonal Transport Vesicle-mediated Transport Interkinetic Nuclear Migration Cytoskeleton-dependent Intracellular Transport Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Protein Transport Along Microtubule Dense Core Granule Cytoskeletal Transport Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs		Natalizumab Hyaluronic acid Nafamostat	Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 21102463) Height ( 31562340) Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low white blood cell count (conditioned on rs2814778) ( 29596498) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Pulse pressure ( 27841878) Soluble ICAM-1 ( 21533024 31217265 18604267) White blood cell count ( 32888494)	Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Response to placebo treatment in childhood asthma (FVC change) ( 31557306)
Interacting Genes		28 interacting genes: BCL7B BRAF CALR CYSRT1 EGFR EZR FANCF FGG HDAC1 HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KIF1A KRTAP10-8 MAP2K7 MC1R MSN MTPN MYO1F SLC3A2 SLCO2B1 SPN TBL3 UBQLN2	27 interacting genes: ADAMTSL4 AR ESR1 FXR2 GIT1 ICAM1 MDFI MED1 MID2 MKRN3 MTUS2 NOTCH2NLA PLSCR1 PPARG PSMA3 RBPMS RFX6 RGS20 RNF31 RXRA SP1 SPRY2 TNS2 TRAF1 TRIM27 TRIP6 TSPOAP1
Entrez ID		3383	547
HPRD ID		00996	03156
Ensembl ID		ENSG00000090339	ENSG00000130294
Uniprot IDs		A0A384MEK5 P05362	A0A3B3IT28 A0A3B3ITE5 A0A3B3IU40 Q12756
PDB IDs		1D3E 1D3I 1D3L 1IAM 1IC1 1IJ4 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U	4EGX 4EJQ 4UXO 4UXP 4UXR 4UXS
Enriched GO Terms of Interacting Partners?
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