APOA4 and CMTM4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		APOA4	CMTM4
Description		apolipoprotein A4	CKLF like MARVEL transmembrane domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Cell Surface Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Integral Component Of Membrane
	Molecular Function	Lipid Transporter Activity Copper Ion Binding Protein Binding Phospholipid Binding Lipid Binding Cholesterol Binding Antioxidant Activity Phosphatidylcholine Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Cholesterol Transfer Activity	Protein Binding
	Biological Process	Innate Immune Response In Mucosa Cholesterol Biosynthetic Process Lipid Transport Response To Lipid Hydroperoxide Leukocyte Cell-cell Adhesion Cholesterol Metabolic Process Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Lipid Catabolic Process Removal Of Superoxide Radicals Regulation Of Intestinal Cholesterol Absorption Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly High-density Lipoprotein Particle Assembly Negative Regulation Of Plasma Lipoprotein Oxidation Response To Stilbenoid Lipoprotein Metabolic Process Cholesterol Homeostasis Hydrogen Peroxide Catabolic Process Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Protein-lipid Complex Assembly Triglyceride Homeostasis Intermembrane Lipid Transfer
Pathways		Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs		Zinc Copper Zinc acetate
Diseases
GWAS		Apolipoprotein A-IV levels ( 27412012) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565) Coronary artery disease ( 29263402) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 20864672 19060906 20686565 26582766) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 20864672 19060911 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolic syndrome ( 30382898) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Total cholesterol levels ( 28334899 29403010 29615537) Triglyceride levels ( 32203549 28334899 26763881 28371326 29615537 32335043) Triglycerides ( 19074352 21909109 18193043 18193044 20864672 19060906 19060911 20139978 20686565 26582766)
Interacting Genes		6 interacting genes: AGTRAP CMTM4 CMTM5 GPLD1 HSP90AA1 MAGEA6	20 interacting genes: APOA4 APPL1 COQ8A DAPK1 DGCR6L DIABLO HSBP1L1 MIDN MRPL2 PBX3 PTPN9 SMG9 SNX1 SPG21 SSX3 STAR TBRG4 TCEA2 TTPA ZFYVE21
Entrez ID		337	146223
HPRD ID		00130	07435
Ensembl ID		ENSG00000110244	ENSG00000183723
Uniprot IDs		P06727	Q8IZR5
PDB IDs		3S84
Enriched GO Terms of Interacting Partners?
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