HSP90AB1 and TPSAB1

		HSP90AB1	TPSAB1
Description		heat shock protein 90 alpha family class B member 1	tryptase alpha/beta 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Cell Surface Membrane Inclusion Body Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Protein-containing Complex Aryl Hydrocarbon Receptor Complex Secretory Granule Lumen Melanosome Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Dynein Axonemal Particle Ficolin-1-rich Granule Lumen HSP90-CDC37 Chaperone Complex Sperm Head Plasma Membrane Ooplasm	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix
	Molecular Function	UTP Binding CTP Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding GTP Binding Sulfonylurea Receptor Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding DATP Binding Peptide Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding ATP-dependent Protein Binding Protein Folding Chaperone Transmembrane Transporter Binding Cadherin Binding Protein Dimerization Activity Tau Protein Binding Unfolded Protein Binding DNA Polymerase Binding Disordered Domain Specific Binding Histone Methyltransferase Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Identical Protein Binding
	Biological Process	Placenta Development Protein Folding Response To Unfolded Protein Telomere Maintenance Via Telomerase Response To Xenobiotic Stimulus Response To Salt Stress Virion Attachment To Host Cell Central Nervous System Neuron Axonogenesis Establishment Of Cell Polarity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Heat Response To Cocaine Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Size Axon Extension Protein Stabilization Chaperone-mediated Protein Complex Assembly Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Telomerase Activity Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Organic Cyclic Compound Positive Regulation Of Protein Serine/threonine Kinase Activity Supramolecular Fiber Organization Negative Regulation Of Transforming Growth Factor Beta Activation Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Tau-protein Kinase Activity Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Cellular Protein Localization Positive Regulation Of Cyclin-dependent Protein Kinase Activity Telomerase Holoenzyme Complex Assembly Positive Regulation Of Protein Localization To Cell Surface	Proteolysis Defense Response Extracellular Matrix Disassembly
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Regulation of actin dynamics for phagocytic cup formation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase HSF1-dependent transactivation Sema3A PAK dependent Axon repulsion Uptake and function of diphtheria toxin Neutrophil degranulation The NLRP3 inflammasome The role of GTSE1 in G2/M progression after G2 checkpoint Aryl hydrocarbon receptor signalling ESR-mediated signaling RHOBTB2 GTPase cycle Estrogen-dependent gene expression Chaperone Mediated Autophagy Purinergic signaling in leishmaniasis infection Potential therapeutics for SARS	Activation of Matrix Metalloproteinases
Drugs		Geldanamycin 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine Radicicol Tanespimycin SNX-5422 CCT-018159 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Polaprezinc	Amido Phenyl Pyruvic Acid 4-PIPERIDIN-4-YLBUTANAL [4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE 1-(1'-{[3-(methylsulfanyl)-2-benzothiophen-1-yl]carbonyl}spiro[1-benzofuran-3,4'-piperidin]-5-yl)methanamine 1-[1'-(3-phenylacryloyl)spiro[1-benzofuran-3,4'-piperidin]-5-yl]methanamine JNJ-27390467
Diseases
GWAS		Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		76 interacting genes: ACD AKT1 ARHGAP1 CCR7 CCT2 CDC37L1 CDKN2A CETN3 CHORDC1 CHUK CLIC4 CSNK2A1 CYP17A1 DDX24 EGFR ENO1 ESR1 ESRRB FCHSD2 GABARAPL1 GABARAPL2 GNPDA1 GPRC5B GSK3A GSK3B HSF1 HSPB1 IKBKB IKBKE IKBKG ITGB1BP2 KEAP1 MAP3K14 MAP3K3 MAPK6 MAST1 MKNK1 MTX2 MYCBP2 NR2C2 NR3C1 NR4A1 OGT PENK POT1 PPID PROS1 PTEN PTGES3 RHOBTB2 SERPINB5 SGTA SHKBP1 SIRPA SLC25A27 SLC34A1 STARD13 STAT1 STAT3 STUB1 SUMO2 TAF1D TBK1 TERF1 TINF2 TNNT1 TP53 TPSAB1 TSSK6 UBE2D3 UBE3A UNC45A USP50 WASL YWHAB ZFP36L2	2 interacting genes: ADAMTS1 HSP90AB1
Entrez ID		3326	7177
HPRD ID		06763	01849
Ensembl ID		ENSG00000096384	ENSG00000172236
Uniprot IDs		A0A024RD80 B4DGL0 P08238 Q6PK50	P20231 Q15661
PDB IDs		1QZ2 1UYM 2L6J 3FWV 3NMQ 3PRY 3UQ3 5FWK 5FWL 5FWM 5FWP 5UC4 5UCH 5UCI 5UCJ 6N8W 6N8Y	1A0L 1AAO 1LTO 2BM2 2F9N 2F9O 2F9P 2FPZ 2FS8 2FS9 2FWW 2FXR 2GDD 2ZA5 2ZEB 2ZEC 3V7T 4A6L 4MPU 4MPV 4MPW 4MPX 4MQA 5F03 5WI6 6O1F 6P0P 6VVU
Enriched GO Terms of Interacting Partners?
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