HSF1 and LY6E

		HSF1	LY6E
Description		heat shock transcription factor 1	lymphocyte antigen 6 family member E
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol PML Body Perinuclear Region Of Cytoplasm Nuclear Stress Granule Mitotic Spindle Pole Chaperone Complex Ribonucleoprotein Complex	Extracellular Region Plasma Membrane Anchored Component Of Membrane Synapse
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Heat Shock Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein Self-association Protein Heterodimerization Activity Hsp90 Protein Binding Translation Elongation Factor Binding STAT Family Protein Binding Sequence-specific Single Stranded DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Protein Binding Acetylcholine Receptor Inhibitor Activity Acetylcholine Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade DNA Repair Regulation Of Transcription By RNA Polymerase II MRNA Processing Defense Response Response To Nutrient Positive Regulation Of Cell Population Proliferation MRNA Transcription Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Activity Negative Regulation Of Protein-containing Complex Assembly Response To Testosterone Cellular Response To Heat Cellular Response To Unfolded Protein Cellular Protein-containing Complex Assembly Cellular Response To Potassium Ion Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Macrophage Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Heat Stress Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Estradiol Stimulus Cellular Response To Gamma Radiation Cellular Response To Diamide Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cellular Response To Heat Positive Regulation Of MRNA Polyadenylation Negative Regulation Of Neuron Death Positive Regulation Of Apoptotic DNA Fragmentation Cellular Response To Sodium Arsenite Cellular Response To Angiotensin Positive Regulation Of Microtubule Binding Cellular Response To Nitroglycerin Cellular Response To L-glutamine Response To Hypobaric Hypoxia Response To Psychosocial Stress Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	In Utero Embryonic Development Cell Surface Receptor Signaling Pathway Adrenal Gland Development Organ Growth Norepinephrine Metabolic Process Negative Regulation Of Viral Entry Into Host Cell Epinephrine Secretion Ventricular Cardiac Muscle Tissue Morphogenesis Acetylcholine Receptor Signaling Pathway Negative Regulation Of Signaling Receptor Activity
Pathways		Regulation of HSF1-mediated heat shock response HSF1 activation Attenuation phase HSF1-dependent transactivation Aggrephagy	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Bimoclomol
Diseases
GWAS		Dupuytren's disease ( 28886342)
Interacting Genes		52 interacting genes: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 EEF1D ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSP90AA1 HSP90AB1 HSPA1A HSPA8 LY6E MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 PIM2 PPID PRKDC PTGES3 RALBP1 REPS1 RNF20 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP UBE2I XRCC5 XRCC6 YWHAE	14 interacting genes: AKR1B1 CD247 EIF3H FCGR2B GLI4 GML GPAA1 HSF1 JRK MFSD6 PIP TMEM140 TMEM19 TRARG1
Entrez ID		3297	4061
HPRD ID		00778	03227
Ensembl ID		ENSG00000185122	ENSG00000160932
Uniprot IDs		Q00613	Q16553
PDB IDs		2LDU 5D5U 5D5V 5HDG 5HDN
Enriched GO Terms of Interacting Partners?
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