HSBP1 and MPP7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HSBP1	MPP7
Description		heat shock factor binding protein 1	MAGUK p55 scaffold protein 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cytoskeleton Axon Cytoplasm	Nucleoplasm Adherens Junction Bicellular Tight Junction Cell Cortex Lateral Plasma Membrane Cell Junction MPP7-DLG1-LIN7 Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Identical Protein Binding	Protein Binding Protein Domain Specific Binding Signaling Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Axonal Transport Of Mitochondrion Endodermal Cell Differentiation Cellular Heat Acclimation	Establishment Of Cell Polarity Positive Regulation Of Protein-containing Complex Assembly Bicellular Tight Junction Assembly Protein Localization To Adherens Junction
Pathways		HSF1 activation Attenuation phase HSF1-dependent transactivation	RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Lead levels ( 26025379) Metabolite levels ( 23823483) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)	Blood protein levels ( 30072576) Bone mineral density ( 24249740) Bone mineral density (paediatric, skull) ( 24945404) Diverticular disease ( 30177863) Glaucoma (primary open-angle) ( 27001270) Heel bone mineral density ( 30598549 28869591) Hippocampal volume ( 21116278) Lumbar spine bone mineral density ( 29499414 22504420) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Psychosis and Alzheimer's disease ( 22005930)
Interacting Genes		25 interacting genes: BLOC1S5 BRK1 CCHCR1 CD1B CYSRT1 GORASP2 HSF1 HSPA1A KIAA1217 KIFC3 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 LNX1 MPHOSPH6 MPP7 NOTCH2NLA RPL13 SDCBP SDCBP2 SDR42E1 WASHC1 WASHC3 ZBTB25	7 interacting genes: DLGAP4 HSBP1 LIN7A LIN7B LIN7C MYSM1 TRIM5
Entrez ID		3281	143098
HPRD ID		05185	14733
Ensembl ID		ENSG00000230989	ENSG00000150054
Uniprot IDs		O75506	Q5T2T1
PDB IDs		3CI9	3LRA 3O46
Enriched GO Terms of Interacting Partners?
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