HOXD8 and DYNC1I2

		HOXD8	DYNC1I2
Description		homeobox D8	dynein cytoplasmic 1 intermediate chain 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	Microtubule Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Anterior/posterior Axis Specification, Embryo Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis	Microtubule-based Movement Transport Along Microtubule
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate (creatinine) ( 28452372) Male-pattern baldness ( 28196072) Urate levels ( 31578528)	Hippocampal volume ( 25625606) Metabolite levels ( 23823483) Refractive error ( 32231278) Weight ( 28552196)
Interacting Genes		9 interacting genes: ANXA7 BAIAP2 CDKN1A DYNC1I2 HMGB1 LDLRAP1 NCK2 PFDN1 RCC1	13 interacting genes: ACTN3 ATP5MC3 CCDC136 CDCA7 DCTN1 DYNLRB1 DYNLT1 DYNLT3 HOXD1 HOXD8 NECAB2 PNN PPFIA1
Entrez ID		3234	1781
HPRD ID		00868	04512
Ensembl ID		ENSG00000175879	ENSG00000077380
Uniprot IDs		A0A0A0MSX5 P13378	A0A140VKE9 B4DPZ3 Q13409
PDB IDs			5JPW 6F1T 6F1U 6F1Z 6F38 6F3A
Enriched GO Terms of Interacting Partners?
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