TLX2 and IRF6

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		TLX2	IRF6
Description		T cell leukemia homeobox 2	interferon regulatory factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Cellular_component Nucleus Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Enteric Nervous System Development Animal Organ Development Negative Regulation Of Dendrite Morphogenesis	Immune System Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Keratinocyte Differentiation Keratinocyte Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Development Regulation Of Cell Cycle Roof Of Mouth Development Limb Development Mammary Gland Epithelial Cell Differentiation Cranial Skeletal System Development
Pathways			Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Alopecia areata ( 25608926) Alzheimer's disease (APOE e4 interaction) ( 25778476) Cleft lip ( 20436469) Cleft lip with or without cleft palate ( 28054174) Crohn's disease ( 28067908) Drug-induced liver injury in interferon-beta-treated multiple sclerosis ( 30013178) Inflammatory bowel disease ( 28067908) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280 33898419) Nonsyndromic cleft palate ( 31609978) Orofacial clefts ( 19270707 22863734 28054174) Systolic blood pressure ( 30224653)
Interacting Genes		11 interacting genes: GTF2A1L IRF6 IRF9 KRTAP6-2 MCM4 MEIS1 POU2F1 POU6F2 TLE1 YWHAH ZNF502	5 interacting genes: CENPF IRF8 RFX3 TLX2 ZBTB3
Entrez ID		3196	3664
HPRD ID		07254	06227
Ensembl ID		ENSG00000115297	ENSG00000117595
Uniprot IDs		O43763	G0Z349 O14896
PDB IDs		3A03
Enriched GO Terms of Interacting Partners?
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