HLX and FOXH1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HLX	FOXH1
Description		H2.0 like homeobox	forkhead box H1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Activin Responsive Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding
	Biological Process	Liver Development Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Skeletal Muscle Tissue Development Positive Regulation Of Cell Population Proliferation Cell Differentiation Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Organ Growth Enteric Nervous System Development Embryonic Digestive Tract Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Pathways			Signaling by NODAL Signaling by Activin
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Body shape index ( 34021172) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal fluid AB1-42 levels ( 26252872) Diverticular disease ( 30177863) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Granulocyte percentage of myeloid white cells ( 27863252) Lung function (FVC) ( 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) PR interval ( 32439900) Triglyceride levels ( 32154731) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412) Waist-hip index ( 34021172) White blood cell count ( 32888494)	Blood metabolite levels ( 26401656) Educational attainment ( 25201988) General cognitive ability ( 29844566)
Interacting Genes		13 interacting genes: ATXN1L C14orf119 CALCOCO2 CYSRT1 DTX2 FOXH1 LONRF1 MIEN1 PRR20A PRR20B PRR20C PRR20D PRR20E	71 interacting genes: AOC1 ARID5A ATP23 ATXN1L BATF2 C10orf55 C11orf1 C19orf54 CEACAM6 CRX CRYBA1 CYSRT1 DAZAP2 DRAP1 FAM168B FAM83A FOXD2 FOXG1 HDHD3 HEY1 HLX HOXA1 HSF4 KLHL26 KRTAP11-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP7-1 LASP1 LRRC14 MAGED1 MGAT5B MSX2 NKX2-5 NOTO OXER1 PLA2G10 PNMA5 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 RBM46 RBPMS2 RECQL4 RNF144B RPL8 SERGEF SMAD2 SMAD3 SMAD4 SOX14 SOX4 SUPT20H TEKT5 TFG TLX3 TSC1 UBAP2 UFSP1 ZC3H10 ZIC1 ZNF34 ZNF503
Entrez ID		3142	8928
HPRD ID		00875	04689
Ensembl ID		ENSG00000136630	ENSG00000160973
Uniprot IDs		Q14774	O75593
PDB IDs			5XOC
Enriched GO Terms of Interacting Partners?
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