HLA-F and LILRB1

Number of citations of the paper that reports this interaction (PubMedID 11169396)
48

Data Source:
HPRD (in vivo)

		HLA-F	LILRB1
Description		major histocompatibility complex, class I, F	leukocyte immunoglobulin like receptor B1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class Ib Protein Complex MHC Class I Protein Complex Recycling Endosome Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding TAP1 Binding TAP2 Binding 14-3-3 Protein Binding	Amyloid-beta Binding Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Complex Binding MHC Class Ib Protein Binding HLA-A Specific Inhibitory MHC Class I Receptor Activity HLA-B Specific Inhibitory MHC Class I Receptor Activity MHC Class I Receptor Activity MHC Class Ib Receptor Activity Inhibitory MHC Class I Receptor Activity SH2 Domain Binding MHC Class I Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Negative Regulation Of T Cell Cytokine Production Negative Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Negative Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Degranulation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Neuron Death	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Adaptive Immune Response T Cell Proliferation Involved In Immune Response Negative Regulation Of Cytokine Production Involved In Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Signal Transduction Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Serotonin Secretion Cytokine-mediated Signaling Pathway Receptor Internalization Negative Regulation Of Interferon-beta Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Alpha-beta T Cell Activation Defense Response To Virus Negative Regulation Of Calcium Ion Transport Positive Regulation Of Macrophage Cytokine Production Cellular Response To Lipopolysaccharide Negative Regulation Of Transforming Growth Factor Beta Production Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Dendritic Cell Differentiation Negative Regulation Of Osteoclast Development
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 22412388) Hip circumference adjusted for BMI ( 34021172) Lung cancer ( 31577861) Mixed cellularity Hodgkin lymphoma ( 29196614) Nasopharyngeal carcinoma ( 19664746) Offspring birth weight ( 31043758)	Blood protein levels ( 30072576 29875488 28240269) Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		5 interacting genes: B2M CHRM5 LILRB1 LILRB2 TAP1	6 interacting genes: B2M HLA-A HLA-B HLA-C HLA-F HLA-G
Entrez ID		3134	10859
HPRD ID		00884	07273
Ensembl ID		ENSG00000204642	ENSG00000104972
Uniprot IDs		P30511 Q5JZ47 Q5JZ48	A0A087WSV6 A0A087WSX8 A0A0B4J1W1 A8MVE2 D9IDM5 Q8NHL6
PDB IDs		5IUE 5KNM	1G0X 1P7Q 1UFU 1UGN 1VDG 3D2U 4LL9 4NO0 5KNM 6AEE 6EWA 6EWC 6EWO 6K60 6ZDX
Enriched GO Terms of Interacting Partners?
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